- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
FOXI1 Antibody / Forkhead Transcription Factor Antibody (FY13299)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY13299 | Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml | 100 ug | 449 |
| Availability | 1-2 days |
| Species Reactivity | Human, Rat |
| Format | Lyophilized |
| Host | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Immunogen affinity purified |
| Buffer | Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.01 mg NaN3. |
| UniProt | Q12951 |
| Applications | Western Blot : 0.25-0.5ug/ml Immunocytochemistry : 5ug/ml Immunofluorescence : 5ug/ml Flow Cytometry : 1-3ug/million cells ELISA : 0.1-0.5ug/ml |
| Limitations | This FOXI1 Antibody / Forkhead Transcription Factor Antibody is available for research use only. |
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Forkhead box protein I1 (FOXI1) is a member of the forkhead box family of transcription factors involved in epithelial differentiation, developmental signaling, and regulation of ion transport-associated gene expression pathways. FOXI1 Antibody / Forkhead Transcription Factor Antibody is suitable for investigations involving epithelial regulatory proteins, developmental transcription factors, and signaling-associated gene expression control mechanisms. FOXI1 belongs to the FOX superfamily of DNA-binding transcriptional regulators characterized by a conserved forkhead domain that coordinates lineage-specific differentiation and tissue-associated transcriptional programs.
FOXI1 antibody, also referred to as Forkhead box I1 antibody, Forkhead transcription factor antibody, HFH-3 antibody, and FKHL10 antibody in the literature, recognizes a transcription-associated regulatory protein strongly linked to epithelial ion transport regulation and developmental tissue specification. FOXI1 expression is enriched within specialized epithelial populations including renal intercalated cells and inner ear epithelial structures, where it contributes to regulation of proton transport and ion homeostasis-associated genes. FOXI1 has been reported to regulate expression of proton pump subunits, ion channels, and epithelial transport-associated proteins required for maintenance of specialized epithelial physiology.
Members of the forkhead transcription factor family regulate diverse biological processes including embryogenesis, organ development, differentiation, metabolism, and adaptive signaling responses. FOXI1 contributes to epithelial maturation pathways and developmental signaling programs associated with acid-base balance, epithelial functional identity, and ion transport regulation. Experimental studies have demonstrated that FOXI1 participates in transcriptional control of pathways required for epithelial specialization and maintenance of tightly regulated transport environments in kidney and inner ear tissues.
Dysregulation of FOXI1-associated transcriptional programs has been linked to developmental abnormalities involving epithelial and sensory systems. Because FOXI1 functions as a lineage-associated transcription factor within ion-transporting epithelial populations, this target is useful for studies examining epithelial differentiation, tissue patterning, and developmental signaling pathways associated with specialized transport functions. FOXI1 has additionally been investigated in relation to epithelial homeostasis mechanisms requiring coordinated transcriptional regulation of transport-associated genes.
Western blot, immunofluorescence, and flow cytometry analyses support detection of endogenous FOXI1 expression across multiple research applications. Immunofluorescence analysis demonstrates strong nuclear-associated staining with additional cytoplasmic signal, consistent with the intracellular localization expected for a forkhead family transcription-associated regulatory protein. The combination of WB, IF, and FACS application data supports use of this rabbit polyclonal antibody for investigations involving epithelial differentiation proteins, developmental signaling pathways, and transcription-associated ion transport regulation.
An antibody targeting FOXI1 can therefore support studies involving forkhead transcription factor biology, epithelial differentiation programs, developmental tissue specification, ion transport-associated gene regulation, and transcriptional control mechanisms involved in epithelial homeostasis.
Explore our FOXI1 Antibody / Forkhead Box Transcription Factor Marker page for additional validation data including HuProt microarray specificity analysis, immunohistochemistry, immunofluorescence, and flow cytometry characterization of FOXI1 expression.
Optimal dilution of the FOXI1 Antibody / Forkhead Transcription Factor Antibody should be determined by the researcher.
E.coli-derived human FOXI1 recombinant protein (Position: M1-V378) was used as the immunogen for the FOXI1 antibody.
After reconstitution, the FOXI1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
FOXI1 antibody, Forkhead box I1 antibody, Forkhead transcription factor antibody, HFH-3 antibody, FKHL10 antibody
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