- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
FLT3 Antibody / Receptor Tyrosine Kinase Marker [clone FLT3/9883] (V5704)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V5704-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V5704-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V5704SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG |
| Clone Name | FLT3/9883 |
| Purity | Protein A/G affinity |
| UniProt | P36888 |
| Localization | Cell membrane, cytoplasm |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This FLT3 Antibody / Receptor Tyrosine Kinase Marker is available for research use only. |
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Fms-like tyrosine kinase 3 (FLT3), also known as CD135, is a class III receptor tyrosine kinase involved in hematopoietic development, progenitor cell signaling, and cytokine-responsive cellular regulation pathways. FLT3 Antibody / Receptor Tyrosine Kinase Marker is suitable for investigations involving hematopoietic signaling, leukemia-associated biology, receptor tyrosine kinase pathways, and cellular differentiation-associated signaling mechanisms. FLT3 is primarily expressed within hematopoietic progenitor populations and participates in pathways regulating proliferation, survival, and developmental signaling responses.
FLT3 antibody, also referred to as CD135 antibody, Fms-like tyrosine kinase 3 antibody, FLK2 antibody, and Hematopoietic receptor tyrosine kinase antibody in the literature, recognizes a transmembrane signaling receptor associated with cytokine-responsive hematopoietic regulation. Binding of FLT3 ligand activates intracellular signaling pathways including PI3K-AKT, MAPK, and STAT-associated regulatory cascades involved in cellular proliferation and developmental signaling control. Through these pathways, FLT3 contributes to maintenance of hematopoietic progenitor cell populations and regulation of lineage-associated differentiation programs.
FLT3 has attracted substantial interest in oncology research because activating FLT3 mutations are among the most clinically significant signaling abnormalities identified in acute myeloid leukemia (AML). Internal tandem duplication (FLT3-ITD) and tyrosine kinase domain mutations can drive constitutive receptor activation and oncogenic signaling. Because of this biology, FLT3 remains widely investigated in leukemia-associated signaling pathways, hematologic malignancy biology, and receptor tyrosine kinase-targeted therapeutic research environments.
Class III receptor tyrosine kinases participate in pathways controlling proliferation, differentiation, cytokine signaling, and developmental cellular responses. FLT3 signaling has additionally been implicated in immune-associated regulatory mechanisms and progenitor cell-associated signaling networks. Because receptor tyrosine kinases influence multiple interconnected signaling pathways, FLT3 remains relevant for investigations involving hematopoietic regulation, leukemia biology, and developmental signaling-associated cellular control mechanisms.
Immunohistochemistry analysis supports detection of endogenous FLT3 expression in human tissue, consistent with the expected distribution pattern of this receptor tyrosine kinase-associated signaling protein. Clone FLT3/9883 mouse monoclonal antibody can support investigations involving leukemia-associated signaling pathways, receptor tyrosine kinase biology, hematopoietic differentiation, and oncology-associated cellular regulation.
An antibody targeting FLT3 can therefore support studies involving hematopoietic progenitor signaling, receptor tyrosine kinase-associated pathways, leukemia biology, cytokine-responsive cellular regulation, and oncogenic signaling-associated cellular mechanisms.
FLT3 participates in hematopoietic signaling and leukemia-associated receptor tyrosine kinase pathways; explore related oncology and signaling proteins on our Cancer Antibodies page.
Optimal dilution of the FLT3 Antibody / Receptor Tyrosine Kinase Marker should be determined by the researcher.
A portion of amino acids 500-800 from human FLT3 protein was used as the immunogen for the FLT3 antibody.
Aliquot the FLT3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
FLT3 antibody, CD135 antibody, Fms-like tyrosine kinase 3 antibody, FLK2 antibody, Hematopoietic receptor tyrosine kinase antibody
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