- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Related Products
|
FLI1 antibody detects Friend leukemia integration 1 transcription factor, encoded by the FLI1 gene. FLI1 belongs to the ETS family of transcription factors and regulates hematopoiesis, vascular development, and cell growth. It is expressed in endothelial cells, megakaryocytes, and hematopoietic progenitors, where it controls genes involved in differentiation and angiogenesis. Because of its developmental roles and involvement in cancers such as Ewing sarcoma, FLI1 antibody is widely applied in research and diagnostic contexts.
FLI1 contains an ETS DNA-binding domain that recognizes GGAA core motifs in promoters and enhancers, activating transcription of target genes. It interacts with cofactors to regulate endothelial stability, megakaryocyte maturation, and immune responses. In vascular biology, FLI1 influences angiogenesis and vessel integrity, while in hematology it contributes to platelet production and immune regulation.
The FLI1 antibody clone FLI1/4371R provides reproducible and specific recognition. Recombinant production ensures batch-to-batch consistency, reducing experimental variability. Peer-reviewed publications have cited FLI1 antibodies in studies of endothelial cell regulation, transcriptional programming in hematopoiesis, and tumor diagnostics, underscoring their value in multiple disciplines.
Research with clone FLI1/4371R has clarified how FLI1 expression marks Ewing sarcoma, where translocations create FLI1 fusion proteins that act as oncogenic drivers. Detection of FLI1 has become an important diagnostic aid in distinguishing Ewing sarcoma from other small round cell tumors. In vascular biology, this antibody supports studies of angiogenesis, vascular remodeling, and endothelial cell signaling. In hematology, it helps map transcriptional networks that regulate megakaryocytes and platelets.
NSJ Bioreagents provides this FLI1 antibody to support oncology, hematology, and vascular biology research. Alternate designations include Friend leukemia virus integration 1 antibody, ETS transcription factor FLI1 antibody, hematopoietic transcription factor antibody, endothelial cell transcriptional regulator antibody, and proto-oncogene FLI1 antibody.
Optimal dilution of the FLI1 antibody should be determined by the researcher.
Recombinant full-length human FLI1 protein was used as the immunogen for the FLI1 antibody.
Aliquot the FLI1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Your bulk quote request has been submitted successfully!
Please contact us if you have any questions.