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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Filaggrin Antibody [clone SPM181] (V3364)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V3364-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
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V3364-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V3364SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | SPM181 |
| Purity | Protein G affinity chromatography |
| Buffer | 1X PBS, pH 7.4 |
| UniProt | P20930 |
| Localization | Cytoplasmic |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This Filaggrin antibody SPM181 is available for research use only. |
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Filaggrin (FLG) is a major epidermal structural protein involved in keratin filament aggregation, epithelial differentiation, and formation of the cutaneous barrier. Filaggrin Antibody / Epidermal Differentiation Marker clone SPM181 is suitable for investigations involving keratinocyte maturation, epidermal barrier biology, stratified squamous epithelium, and dermatopathology-associated signaling pathways. Filaggrin is synthesized as the precursor protein profilaggrin within keratohyalin granules and is subsequently processed into functional monomers that contribute to epidermal barrier integrity and epithelial mechanical stability.
Filaggrin antibody, also referred to as FLG antibody, Epidermal barrier protein antibody, and Keratinocyte differentiation marker antibody in the literature, recognizes a protein highly enriched within differentiated suprabasal epidermal layers. Filaggrin promotes aggregation of keratin intermediate filaments during terminal epithelial differentiation and contributes to formation of the stratum corneum and cornified envelope. Because of its restricted epithelial distribution and strong association with epidermal maturation, Filaggrin remains an important biomarker in skin biology and epithelial differentiation research.
Altered Filaggrin expression and FLG gene mutations have been associated with atopic dermatitis, ichthyosis vulgaris, allergic sensitization disorders, and epithelial barrier dysfunction syndromes. The protein is therefore widely investigated in dermatology, epithelial pathology, and inflammatory skin disease research. Filaggrin additionally contributes to epidermal hydration pathways through generation of natural moisturizing factor components during protein degradation.
Clone SPM181 antibody has been referenced in multiple peer-reviewed publications involving epidermal differentiation, epithelial barrier biology, and skin-associated pathology research applications. This mouse monoclonal antibody can support investigations involving keratinocyte maturation, epidermal structure, epithelial differentiation pathways, and dermatopathology-associated signaling mechanisms.
Explore our Filaggrin Antibody / Epidermal Differentiation Marker page for additional validation data and research applications involving keratinocyte maturation, epithelial barrier biology, and dermatopathology-associated signaling pathways.
Optimal dilution of the Filaggrin antibody SPM181 should be determined by the researcher.
A recombinant human FLG protein was used as the immunogen for this Filaggrin antibody.
Store the Filaggrin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Filaggrin antibody, FLG antibody, Filaggrin clone SPM181 antibody, Epidermal barrier protein antibody, Keratinocyte differentiation marker antibody
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