- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Filaggrin Antibody [clone FLG/1562] (V3331)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V3331-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 539 | |
|
|
V3331-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 249 | |
|
|
V3331SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 539 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | FLG/1562 |
| Purity | Protein G affinity chromatography |
| Buffer | 1X PBS, pH 7.4 |
| UniProt | P20930 |
| Localization | Cytoplasmic |
| Applications | Immunohistochemistry (FFPE) : 0.5-1ug/ml for 30 min at RT |
| Limitations | This Filaggrin antibody is available for research use only. |
|
Review this product on BioCompare and get a $20 Amazon gift card
|
Related Products
|
Filaggrin antibody is an important reagent for research into the molecular mechanisms underlying skin barrier formation. Filaggrin, encoded by the FLG gene, is a filament aggregating protein expressed in the outer layers of the epidermis. Initially synthesized as profilaggrin, it undergoes proteolytic processing during keratinocyte differentiation to generate functional filaggrin monomers. These monomers facilitate keratin filament aggregation, producing the dense, flattened cells that form the protective barrier of the stratum corneum.
The biological role of filaggrin extends beyond structural support. Breakdown products of filaggrin include amino acids and derivatives that function as natural moisturizing factors. These molecules maintain skin hydration, contribute to acid mantle formation, and protect against environmental stressors. Alterations in filaggrin synthesis or processing can compromise barrier integrity, leading to dry skin and increased sensitivity to allergens and microbes.
The Filaggrin antibody clone FLG/1562 enables precise detection of this protein in epidermal samples. Clone FLG/1562 has been widely used to investigate keratinocyte differentiation, epidermal barrier assembly, and the pathophysiology of atopic disorders. Its dependable specificity ensures reproducible results across diverse research contexts, making it an essential tool for dermatology research.
Deficiency or mutation in the FLG gene is among the most significant genetic risk factors for atopic dermatitis and other barrier related conditions. Studies using clone FLG/1562 have clarified how impaired filaggrin expression contributes to these diseases, supporting the development of strategies aimed at restoring barrier function. Research on filaggrin also informs cosmetic science and environmental health, where skin hydration and protection are key factors.
NSJ Bioreagents provides this Filaggrin antibody to researchers focused on skin biology and related disorders. Alternate names such as FLG antibody, profilaggrin antibody, epidermal barrier protein antibody, and keratohyalin granule protein antibody are also commonly used, illustrating the variety of terminology associated with this crucial epidermal component.
Optimal dilution of the Filaggrin antibody should be determined by the researcher.
Amino acids 198-288 of human FLG were used as the immunogen for this Filaggrin antibody.
Store the Filaggrin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Your bulk quote request has been submitted successfully!
Please contact us if you have any questions.
Powered by Bioz
Citations(15)