UBD Antibody / Ubiquitin-Like Modifier Antibody (R31346)

UBD Antibody Human Cell Line Panel WB. Western blot analysis of UBD expression was performed using anti-UBD antibody in multiple human cell line lysates. Lane 1: HeLa. Lane 2: SKOV. Lane 3: MCF-7. Lane 4: A549. Lane 5: SMMC-7721. UBD, also known as FAT10 (Ubiquitin D), is a ubiquitin-like modifier that targets substrate proteins for proteasomal degradation and participates in immune regulation, inflammatory signaling, and cellular stress responses. A specific immunoreactive band is detected at approximately 18–22 kDa in all five cell lines, corresponding to the expected molecular weight range of UBD. The broad expression profile across diverse human cancer cell lines supports the utility of UBD Antibody for studies of ubiquitin-like protein conjugation, proteasomal degradation, immune signaling, inflammation, and cancer biology.

UBD Antibody Human Intestinal Cancer IHC. IHC staining of FFPE human intestinal cancer tissue with UBD antibody demonstrated moderate to strong cytoplasmic staining within malignant cells and adjacent stromal components, consistent with the expression pattern of UBD (Ubiquitin D), also known as FAT10. UBD is a ubiquitin-like modifier that targets proteins for proteasomal degradation and is induced by pro-inflammatory cytokines including interferon-γ and TNF-α. Increased UBD expression has been reported in gastrointestinal malignancies, where it has been associated with inflammation, altered protein homeostasis, and tumor progression. The observed staining supports the utility of UBD Antibody for studies of ubiquitin-like protein conjugation, proteasomal degradation, immune signaling, and cancer biology. Immunohistochemistry was performed on formalin-fixed, paraffin-embedded human intestinal cancer tissue.

UBD Antibody Human Tonsil IHC. IHC staining of FFPE human tonsil tissue with UBD antibody demonstrated prominent cytoplasmic staining in lymphoid cells within the tonsillar follicles and surrounding immune cell populations, consistent with the expression pattern of UBD (Ubiquitin D), also known as FAT10. UBD is a ubiquitin-like modifier that is strongly induced by the pro-inflammatory cytokines interferon-γ and TNF-α and plays important roles in proteasomal degradation, antigen processing, and immune regulation. The abundant staining observed in this lymphoid tissue is consistent with the established role of UBD in activated immune cells and inflammatory responses. These results support the utility of UBD Antibody for studies of ubiquitin-like protein conjugation, immune signaling, inflammation, and lymphoid tissue biology. Immunohistochemistry was performed on formalin-fixed, paraffin-embedded human tonsil tissue.