- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Fast-Spiking Interneuron Marker Antibody / Parvalbumin [clone PVALB/12610R] (V5984)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V5984-100UG | 0.2 mg/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide | 100 ug | 559 | |
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V5984-20UG | 0.2 mg/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide | 20 ug | 259 | |
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V5984SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
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| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | PVALB/12610R |
| UniProt | P20472 |
| Localization | Nucleus, Cytoplasm, Cell junctions |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml Western Blot : 2-4ug/ml |
| Limitations | This Fast-Spiking Interneuron Marker/Parvalbumin antibody is available for research use only. |
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Fast-Spiking Interneuron Marker antibody, also known as Parvalbumin antibody, recognizes Parvalbumin, a small cytosolic EF-hand calcium-binding protein encoded by the human PVALB gene on chromosome 22q12.3. Commonly referred to as Parvalbumin or PV in the neuroscience literature, this protein is predominantly localized to the cytoplasm and is highly expressed in fast-spiking GABAergic interneurons of the cerebral cortex, hippocampus, and cerebellum. It is also present in fast-twitch skeletal muscle fibers. Fast-Spiking Interneuron Marker antibody is widely used to identify interneuron subpopulations that regulate cortical excitability and synchronize neuronal network activity.
Parvalbumin functions primarily as an intracellular calcium buffer. Structurally, it contains three EF-hand motifs, two of which are functional calcium-binding domains capable of binding calcium with high affinity. This buffering capacity allows rapid sequestration of calcium following action potentials, supporting high-frequency firing and precise synaptic timing in inhibitory interneurons. In skeletal muscle, Parvalbumin accelerates relaxation after contraction, particularly in glycolytic fast-twitch fibers. During postnatal brain development, Parvalbumin expression increases as inhibitory circuits mature and gamma oscillatory activity becomes established.
Within the central nervous system, Parvalbumin-positive interneurons often co-localize with synaptic proteins involved in vesicle release and cytoskeletal organization, reflecting their specialization for rapid neurotransmission. Disruption of Parvalbumin-expressing interneurons has been associated with neurological and psychiatric conditions including epilepsy, schizophrenia, and autism spectrum disorders, where altered inhibitory tone and impaired network synchronization are implicated. In muscle biology, Parvalbumin expression correlates with fiber type specification and metabolic properties.
Fast-Spiking Interneuron Marker antibody is suitable for detecting Parvalbumin expression in studies of neural circuitry, neurodevelopment, and muscle physiology. Recombinant monoclonal clone PVALB/12610R is produced using defined expression systems to promote lot-to-lot consistency and reliable performance. A Parvalbumin antibody such as clone PVALB/12610R supports research focused on inhibitory interneuron identification and calcium-buffering protein analysis.
Optimal dilution of the Fast-Spiking Interneuron Marker/Parvalbumin antibody should be determined by the researcher.
Recombinant full-length human PVALB protein was used as the immunogen for the Fast-Spiking Interneuron Marker/Parvalbumin antibody.
Fast-Spiking Interneuron Marker/Parvalbumin antibody with sodium azide - store at 2 to 8oC; antibody without sodium azide - store at -20 to -80oC.
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