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Home >> Antibodies >> Fas Antibody

Fas Antibody [clone 8C1-B9-F12] (F54056)

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  Catalog No Formulation Size Price (USD)  
Image F54056-0.1ML In PBS with 50% glycerol and 0.03% ProClin 300 0.1 ml 399
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Western blot testing of 1) human K562, 2) human Jurkat, 3) rat brain and 4) human Ramos lysates using Fas antibody at 1:1000. Predicted molecular weight: ~38 kDa (unmodified), 40-55 kDa (glycosylated).
Western blot testing of 1) human K562, 2) human Jurkat, 3) rat brain and 4) human Ramos lysates using Fas antibody at 1:1000. Predicted molecular weight: ~38 kDa (unmodified), 40-55 kDa (glycosylated).
Availability 1-3 business days
Species Reactivity Human, Rat
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse lgG2b
Clone Name 8C1-B9-F12
Purity Protein G affinity
UniProt P25445
Applications Western blot : 1:1000
Limitations This Fas antibody is available for research use only.
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Description

Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). [UniProt]

Application Notes

The stated application concentrations are suggested starting points. Titration of the Fas antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A human recombinant protein was used as the immunogen for this Fas antibody.

Storage

Store the Fas antibody at -20oC.

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