- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
FAK Antibody / Focal Adhesion Kinase / PTK2 (R32191)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
R32191 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 439 |
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse, Rat |
| Format | Antigen affinity purified |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity |
| Buffer | Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide |
| UniProt | Q05397 |
| Localization | Cell junctions, cytoplasm, nucleus |
| Applications | Western Blot : 0.5-1ug/ml Immunohistochemistry (FFPE) : 2-5ug/ml |
| Limitations | This FAK antibody is available for research use only. |
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FAK (Focal Adhesion Kinase) is a cytoplasmic non-receptor tyrosine kinase that plays a central role in integrin-mediated signal transduction. It is activated at focal adhesion sites, where cells attach to the extracellular matrix, and functions as a key regulator of cell adhesion, migration, survival, and proliferation. Because of its involvement in diverse cellular processes, a FAK antibody is widely used in research focused on cell signaling, cancer progression, and tissue remodeling.
Upon integrin engagement or stimulation by growth factors, FAK undergoes autophosphorylation at tyrosine 397, creating a docking site for Src-family kinases and other signaling molecules. This interaction initiates downstream pathways such as MAPK, PI3K-AKT, and Rho GTPase signaling, which together coordinate cytoskeletal reorganization and cell motility. Employing a FAK antibody enables researchers to track activation states and protein localization in studies of mechanotransduction and adhesion dynamics.
FAK has been extensively studied in cancer biology due to its role in tumor cell invasion, angiogenesis, and metastasis. Overexpression or hyperactivation of FAK is frequently observed in solid tumors, making it an attractive target for therapeutic intervention. Beyond oncology, FAK is also important in wound healing, cardiovascular disease, and stem cell biology. Using a FAK antibody provides valuable insight into these areas by allowing precise detection of FAK expression and activity.
NSJ Bioreagents offers a high-quality FAK antibody validated for applications including western blot, immunohistochemistry, and immunofluorescence. Choosing a FAK antibody from NSJ Bioreagents ensures accuracy and reproducibility in studies of adhesion signaling, cytoskeletal regulation, and disease pathways.
Optimal dilution of the FAK antibody should be determined by the researcher.
Amino acids AHALAVDAKNLLDVIDQARLKMLGQTRPH of human PTK2/FAK were used as the immunogen for the FAK antibody.
After reconstitution, the FAK antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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