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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Factor XIIIa Antibody Rabbit Monoclonal [clone ACGC-6] (RQ4836)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
RQ4836 | Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA | 100 ul | 449 |
| Availability | 1-2 weeks |
| Species Reactivity | Human, Rat |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Clone Name | ACGC-6 |
| Purity | Affinity purified |
| UniProt | P00488 |
| Localization | Cytoplasmic, secreted |
| Applications | Western Blot : 1:500 Immunohistochemistry (FFPE) : 1:50 |
| Limitations | This Factor XIIIa antibody is available for research use only. |
|
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Factor XIIIa Antibody Rabbit Monoclonal clone ACGC-6 recognizes Factor XIII A chain, a cytoplasmic transglutaminase encoded by the F13A1 gene on chromosome 6p25.1. Factor XIII A chain is primarily expressed in platelets, macrophages, dermal dendritic cells, and subsets of stromal cells. Upon activation by thrombin and calcium, the inactive coagulation factor XIII zymogen is cleaved to generate active Factor XIIIa, which catalyzes covalent cross-linking of fibrin monomers. This enzymatic cross-linking stabilizes fibrin clots and increases resistance to fibrinolysis, representing the final step of the coagulation cascade.
Factor XIII A chain belongs to the transglutaminase enzyme family and contains a catalytic core domain responsible for forming epsilon-gamma glutamyl-lysine isopeptide bonds between substrate proteins. In circulation, coagulation factor XIII exists as a heterotetramer composed of two catalytic A subunits and two non-catalytic B subunits. After proteolytic activation, the B subunits dissociate and the A subunits become enzymatically active. Beyond clot stabilization, Factor XIIIa plays a role in extracellular matrix remodeling through cross-linking of fibronectin, collagen, and other structural proteins, thereby supporting tissue repair and wound healing processes.
In normal tissues, Factor XIII A chain is highly expressed in dermal dendrocytes of the skin and in tissue macrophages. It is also detectable in placenta and bone marrow-derived cells. In fibrohistiocytic lesions, Factor XIIIa antibody staining is widely used to characterize dermatofibroma, which typically demonstrates strong cytoplasmic positivity in spindle-shaped dermal cells. In contrast, dermatofibrosarcoma protuberans generally lacks staining, making this marker useful in differential assessment. Expression has also been observed in inflammatory and reparative conditions where macrophage activation and stromal remodeling are present.
Inherited deficiency of Factor XIII is associated with impaired clot stability, delayed wound healing, and bleeding diathesis, underscoring the biologic importance of F13A1 function. Altered expression patterns have been described in inflammatory and fibrotic conditions, reflecting its involvement in immune cell biology and extracellular matrix stabilization. Factor XIIIa Antibody Rabbit Monoclonal is suitable for detecting Factor XIII A chain expression in relevant research applications, where staining is typically cytoplasmic in positive dendritic or macrophage-lineage cells.
Optimal dilution of the Factor XIIIa antibody should be determined by the researcher.
A synthetic peptide specific to human Factor XIIIa / F13A1 was used as the immunogen for the Factor XIIIa antibody rabbit monoclonal clone ACGC-6.
Store the Factor XIIIa antibody at -20oC.
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