- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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Fatty acid-binding protein 5 (FABP5) is a small cytoplasmic lipid-binding protein involved in intracellular fatty acid trafficking, lipid signaling, and metabolic regulation in epithelial, neural, immune, and tumor-associated cell populations. FABP5 Antibody / Fatty Acid Transport and Metabolism Marker is useful for studying cellular lipid handling, epidermal differentiation, cancer metabolism, and fatty acid-dependent signaling pathways. FABP5 belongs to the fatty acid-binding protein family and is highly expressed in skin, keratinocytes, brain, liver, macrophages, and multiple epithelial-derived tumors.
FABP5 antibody, also known as Epidermal fatty acid binding protein antibody or E-FABP antibody in the literature, recognizes a cytoplasmic fatty acid transport protein that binds long-chain fatty acids and hydrophobic ligands within the intracellular environment. FABP5 participates in transport of fatty acids to metabolic and signaling pathways involved in beta-oxidation, membrane synthesis, inflammatory signaling, and nuclear receptor activation. The protein has been linked to PPAR signaling pathways and regulation of cellular responses to metabolic stress, differentiation cues, and lipid availability.
FABP5 is particularly well known for its role in epidermal biology and keratinocyte metabolism. Strong expression is observed in skin and epithelial tissues where FABP5 contributes to cutaneous lipid homeostasis, barrier function, and epidermal differentiation. Elevated FABP5 expression has additionally been associated with psoriasis, inflammatory skin disease, wound healing responses, and epithelial stress signaling. In cancer biology, FABP5 has attracted attention as a regulator of tumor metabolism, proliferation, migration, and metastatic progression in breast, prostate, colorectal, and squamous carcinomas. Increased FABP5 expression has been linked to aggressive tumor phenotypes and altered lipid utilization programs in malignant cells.
Beyond epithelial tissues, FABP5 is also expressed in brain and immune-associated cell populations where it contributes to neural lipid signaling, inflammatory responses, and cellular metabolic adaptation. The protein has been implicated in macrophage activation, neuroinflammatory signaling, and regulation of oxidative stress pathways. Due to its broad biological importance, FABP5 remains an important research target in metabolism, dermatology, oncology, immunology, and neurobiology studies.
FABP5 Antibody / Fatty Acid Transport and Metabolism Marker clone FABP5/3750 is supported by western blot, immunohistochemistry, and HuProt microarray specificity validation data. Western blot analysis demonstrates the expected low molecular weight FABP5 band in epithelial and proliferative cell samples, while immunohistochemistry supports tissue-specific expression analysis in metabolically active tissues. The included HuProt microarray specificity validation data further supports selective target recognition suitable for studies involving lipid metabolism, epidermal biology, and cancer-associated metabolic signaling pathways.
Explore additional metabolism-associated targets in our Metabolism Antibodies page featuring markers involved in fatty acid transport, lipid signaling, mitochondrial energetics, and cellular metabolic regulation.
Optimal dilution of the FABP5 Antibody / Fatty Acid Transport and Metabolism Marker should be determined by the researcher.
Recombinant full length human protein was used as the immunogen for the FABP5 antibody.
Store the FABP5 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Epidermal fatty acid binding protein antibody, E-FABP antibody, Psoriasis-associated fatty acid-binding protein antibody, Keratinocyte fatty acid transport antibody, FABP5 metabolism marker antibody
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