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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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FABP4 antibody recognizes Fatty acid-binding protein 4, a cytoplasmic lipid chaperone encoded by the FABP4 gene that functions in intracellular fatty acid transport and metabolic signaling regulation. FABP4 antibody, also referred to as Adipocyte fatty acid-binding protein antibody and aP2 antibody in the literature, is widely used in adipocyte biology, metabolic disease, and inflammatory signaling research due to the central role of FABP4 in lipid handling and energy homeostasis. FABP4 is predominantly localized within the cytoplasm of adipocytes and macrophages where it binds long-chain fatty acids and coordinates intracellular lipid trafficking pathways.
FABP4 is located on chromosome 8q21.13 and belongs to the fatty acid-binding protein family of small lipid transport proteins. The protein contains a characteristic beta-barrel lipid-binding domain that accommodates hydrophobic fatty acid ligands and other lipid mediators. Through interactions with metabolic enzymes, nuclear receptors, and inflammatory signaling pathways, FABP4 contributes to regulation of lipid storage, fatty acid oxidation, insulin sensitivity, and cytokine-associated metabolic responses. FABP4 also influences PPAR signaling and macrophage inflammatory activation associated with obesity-related metabolic dysfunction.
The FABP4 Antibody / Adipocyte Lipid Metabolism Marker format is especially relevant for studies investigating obesity, insulin resistance, type 2 diabetes, atherosclerosis, and adipocyte differentiation. FABP4 expression is highly enriched in adipose tissue and is strongly associated with mature adipocyte phenotypes and lipid accumulation states. Increased FABP4 activity has been linked to metabolic syndrome, vascular inflammation, hepatic steatosis, and chronic inflammatory conditions associated with altered lipid homeostasis.
In macrophages, FABP4 participates in inflammatory signaling and cholesterol handling pathways that contribute to foam cell formation and atherosclerotic plaque development. Elevated FABP4 expression has also been associated with tumor-associated adipocyte signaling and metabolic remodeling within the cancer microenvironment. Because FABP4 integrates metabolic and inflammatory signaling networks, it has become an important biomarker in studies examining obesity-associated disease progression and lipid-mediated cellular stress responses.
FABP4 expression is commonly observed in adipocytes, macrophages, and metabolically active stromal cell populations where intracellular fatty acid trafficking and lipid buffering are required for cellular homeostasis. Cytoplasmic localization patterns are typically observed in adipose-associated tissue and inflammatory microenvironment studies, reflecting the soluble intracellular transport functions of FABP4.
Clone FABP4/4424 is useful for investigating adipocyte differentiation, lipid metabolism signaling, macrophage-associated inflammatory pathways, and obesity-related metabolic disease biology. HuProt protein microarray specificity validation further supports selective target recognition for FABP4, making this antibody valuable for studies examining adipocyte-associated metabolic regulation, fatty acid transport mechanisms, and inflammatory lipid signaling pathways.
Explore additional metabolic signaling and lipid regulation targets in our Metabolism Antibodies collection featuring biomarkers involved in adipocyte biology, fatty acid transport, and energy homeostasis research.
Optimal dilution of the FABP4 Antibody / Adipocyte Lipid Metabolism Marker should be determined by the researcher.
A portion of amino acids 1-132 was used as the immunogen for the FABP4 antibody.
Aliquot the FABP4 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
FABP4 antibody, Adipocyte FABP antibody, Adipocyte fatty acid-binding protein antibody, aP2 antibody, Fatty acid-binding protein 4 antibody, FABP4 metabolic marker antibody
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