- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
FABP3 Antibody (cardiac) (RQ4456)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
RQ4456 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 439 |
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse, Rat |
| Format | Antigen affinity purified |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide |
| UniProt | P05413 |
| Localization | Cytoplasm |
| Applications | Western Blot : 0.5-1ug/ml Immunohistochemistry (FFPE) : 1-2ug/ml Direct ELISA : 0.1-0.5ug/ml (recombinant human protein) |
| Limitations | This FABP3 antibody is available for research use only. |
|
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FABP3 antibody detects Heart-type fatty acid binding protein, a small cytoplasmic protein involved in the transport and metabolism of long-chain fatty acids. The UniProt recommended name is Fatty acid-binding protein, heart (FABP3). This protein plays a vital role in cardiac energy metabolism by facilitating the intracellular trafficking of fatty acids to sites of oxidation, storage, or membrane synthesis.
Functionally, FABP3 antibody identifies a 133-amino-acid cytoplasmic lipid chaperone abundantly expressed in cardiac and skeletal muscle. FABP3 binds long-chain fatty acids, acyl-CoA, and other hydrophobic ligands with high affinity, maintaining lipid solubility and availability for mitochondrial β-oxidation. By buffering intracellular fatty acid concentrations, FABP3 supports efficient energy production and prevents lipotoxic stress in metabolically active tissues. It also interacts with peroxisome proliferator-activated receptors (PPARs), influencing gene expression linked to lipid metabolism and energy homeostasis.
The FABP3 gene is located on chromosome 1p33-p32 and is highly expressed in myocardium, slow-twitch skeletal muscle fibers, and to a lesser extent in neurons. Expression levels increase in response to energy demand, ischemic stress, and metabolic adaptation, highlighting its role as a marker of myocardial injury and oxidative metabolism. FABP3 functions as part of a family of fatty acid-binding proteins with distinct tissue distributions and substrate preferences.
Pathologically, elevated FABP3 levels in plasma serve as an early biomarker for acute myocardial infarction and cardiac ischemia, often rising before troponins. Abnormal expression is also associated with metabolic syndromes, neurodegenerative diseases, and cardiomyopathies linked to disrupted lipid utilization. Research using FABP3 antibody supports studies in cardiac metabolism, ischemic injury, and lipid signaling.
FABP3 antibody is validated for use in relevant research applications to detect heart-type fatty acid binding protein and investigate lipid transport and metabolic regulation in muscle tissues. NSJ Bioreagents provides FABP3 antibody reagents optimized for studies in cardiovascular biology, metabolism, and cellular lipid handling.
Optimal dilution of the FABP3 antibody should be determined by the researcher.
Human Cardiac FABP recombinant protein (amino acids V2-A133) was used as the immunogen for the FABP3 antibody.
After reconstitution, the FABP3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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