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- Tel: 858.663.9055
- Email: info@nsjbio.com
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Fatty acid binding protein 2 is a small cytoplasmic lipid chaperone encoded by the FABP2 gene and is also widely referred to as intestinal fatty acid binding protein, I-FABP, or IFABP. FABP2 is a member of the fatty acid binding protein family, a group of low molecular weight intracellular proteins that bind long-chain fatty acids and other hydrophobic ligands to facilitate their intracellular trafficking. This FABP2 antibody targets Fatty acid binding protein 2, which is characteristically localized to the cytoplasm of absorptive epithelial cells in the small intestine, where it plays a central role in dietary lipid handling.
Fatty acid binding protein 2 is highly enriched in enterocytes of the jejunum and ileum, reflecting its specialized function in intestinal lipid absorption. By binding free fatty acids taken up from the intestinal lumen, FABP2 supports intracellular transport to sites of esterification, oxidation, or incorporation into lipoproteins. This places Fatty acid binding protein 2 at a critical junction between nutrient uptake and systemic lipid metabolism. As a member of the FABP family, FABP2 shares a conserved beta-barrel structure that forms a hydrophobic ligand-binding pocket, while maintaining tissue-specific expression patterns that distinguish it from other FABP isoforms.
Beyond its physiological role, Fatty acid binding protein 2 has gained significance as a biomarker in gastrointestinal research. Intestinal fatty acid binding protein is rapidly released into circulation following enterocyte injury, making FABP2 a useful indicator of intestinal epithelial damage in conditions such as ischemia, inflammatory bowel disease, and sepsis-associated gut barrier dysfunction. For this reason, FABP2 antibody reagents are frequently used to study intestinal integrity, epithelial turnover, and disease-associated alterations in lipid handling. The clone FABP2/6344 is designed to detect Fatty acid binding protein 2 expression in research applications, supporting studies of normal intestinal biology as well as pathological states involving epithelial injury or altered metabolism.
At the cellular level, Fatty acid binding protein 2 is predominantly cytoplasmic, consistent with its role in intracellular lipid transport. Expression is largely restricted to differentiated absorptive epithelial cells rather than crypt progenitors, aligning FABP2 expression with mature enterocyte function. This restricted expression profile contributes to the specificity of Fatty acid binding protein 2 as a marker of small intestinal epithelium and distinguishes it from other fatty acid binding proteins expressed in liver, adipose tissue, or immune cells.
Optimal dilution of the FABP2/Fatty acid binding protein 2 antibody should be determined by the researcher.
A recombinant fragment (around amino acids 1-132) of human FABP2 protein (exact sequence is proprietary) was used as the immunogen for the FABP2/Fatty acid binding protein 2 antibody.
FABP2/Fatty acid binding protein 2 antibody with sodium azide - store at 2 to 8oC; antibody without sodium azide - store at -20 to -80oC.
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