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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
FABP1 Antibody - HuProt Validation [clone FABP1/3487] (V8541)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V8541-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
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V8541-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V8541SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2b, kappa |
| Clone Name | FABP1/3487 |
| Purity | Protein G affinity chromatography |
| UniProt | P07148 |
| Localization | Cytoplasmic and Nuclear |
| Applications | Western Blot : 1-2ug/ml Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This FABP1 antibody is available for research use only. |
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FABP1 Antibody - HuProt Validation clone FABP1/3487 recognizes Liver fatty acid binding protein, also known as FABP1 or L-FABP, a cytoplasmic lipid binding protein encoded by the FABP1 gene on chromosome 2p11.2. Liver fatty acid binding protein is abundantly expressed in hepatocytes and functions as an intracellular lipid chaperone that regulates the uptake, trafficking, and metabolism of long chain fatty acids. FABP1 is a member of the fatty acid binding protein family, a group of small cytoplasmic proteins that coordinate lipid homeostasis and lipid-mediated signaling pathways.
Structurally, FABP1 contains a conserved beta barrel motif that forms a hydrophobic ligand binding pocket. This configuration enables binding of long chain fatty acids, bile acids, eicosanoids, and other hydrophobic ligands, facilitating their solubilization and intracellular transport. In hepatocytes, FABP1 contributes to fatty acid uptake, beta oxidation, triglyceride synthesis, and protection against lipotoxic stress. Through these functions, Liver fatty acid binding protein plays an essential role in hepatic energy metabolism and regulation of lipid balance.
In normal tissues, FABP1 expression is strongest in liver, where it localizes to the cytoplasm of hepatocytes. Lower levels of expression are observed in kidney proximal tubule epithelium and small intestinal enterocytes. Because of its abundant and relatively tissue-restricted distribution, FABP1 antibody is widely used in research to study hepatocellular differentiation, metabolic regulation, and liver-associated disease models. Cytoplasmic staining in hepatocytes represents the expected localization pattern.
Clone FABP1/3487 has been validated using the HuProt(TM) human protein microarray platform containing more than 19,000 full-length human proteins. HuProt validation demonstrates strong target selectivity for FABP1 with clear separation from unrelated proteins, supporting high specificity and minimal cross-reactivity. FABP1 Antibody - HuProt Validation clone FABP1/3487 is suitable for detecting Liver fatty acid binding protein expression in relevant research applications involving hepatic biology and lipid metabolism.
Optimal dilution of the FABP1 antibody should be determined by the researcher.
A portion of amino acids 1-127 from the human protein was used as the immunogen for the FABP1 antibody with HuProt validation.
Store the FABP1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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