- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
FABP1 Antibody / Lipid Metabolism Marker Antibody [clone FABP1/3487] (V8541)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V8541-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
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V8541-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V8541SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2b, kappa |
| Clone Name | FABP1/3487 |
| Purity | Protein G affinity chromatography |
| UniProt | P07148 |
| Localization | Cytoplasmic and Nuclear |
| Applications | Western Blot : 1-2ug/ml Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This FABP1 Antibody / Lipid Metabolism Marker Antibody is available for research use only. |
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Fatty acid-binding protein 1 (FABP1) is a small cytoplasmic lipid-binding protein encoded by the FABP1 gene and highly expressed in hepatocytes and intestinal epithelial cells where it supports intracellular fatty acid trafficking and metabolic regulation. FABP1 Antibody / Lipid Metabolism Marker Antibody is useful for studying lipid absorption, fatty acid transport, metabolic adaptation, and epithelial cell biology in normal and diseased tissues. FABP1 belongs to the fatty acid-binding protein family, a group of structurally related proteins that bind long-chain fatty acids and other hydrophobic ligands within the cytoplasm.
FABP1 antibody, also known as Liver fatty acid-binding protein antibody or L-FABP antibody in the literature, recognizes a protein that plays an important role in lipid homeostasis, triglyceride metabolism, beta-oxidation pathways, and cellular responses to metabolic stress. FABP1 is primarily localized to the cytoplasm where it facilitates intracellular movement of fatty acids to organelles involved in oxidation, storage, and membrane synthesis. The protein is especially abundant in liver and intestine, reflecting the central role of these tissues in dietary lipid processing and systemic metabolic regulation.
FABP1 expression is commonly associated with differentiated absorptive epithelial cells of the intestine and metabolically active hepatocytes. In immunohistochemistry studies, FABP1 staining is frequently observed as strong cytoplasmic labeling in intestinal enterocytes and liver parenchymal cells, making the protein a useful marker for gastrointestinal and hepatic tissue characterization. Altered FABP1 expression has also been investigated in colorectal carcinoma, hepatocellular carcinoma, gastric cancer, and other epithelial malignancies where changes in lipid metabolism contribute to tumor progression and metabolic remodeling.
FABP1 participates in multiple metabolic signaling pathways linked to lipid uptake, peroxisome proliferator-activated receptor (PPAR) activity, oxidative stress responses, and energy homeostasis. The protein can bind a broad spectrum of hydrophobic molecules including saturated and unsaturated fatty acids, eicosanoids, and bile acid-related metabolites. Through these interactions, FABP1 contributes to cellular protection against lipotoxicity and oxidative injury while supporting efficient fatty acid utilization in tissues with high metabolic demand.
FABP1 is encoded on human chromosome 2p11 and produces a highly conserved protein structure characterized by a beta-barrel lipid-binding domain typical of the FABP family. The compact cytoplasmic protein architecture enables rapid ligand exchange and intracellular trafficking functions important for nutrient absorption and metabolic adaptation. Due to its strong enrichment in liver and intestinal epithelium, FABP1 is frequently used as a marker of enterocyte differentiation, hepatocellular identity, and epithelial metabolic function.
Clone FABP1/3487 has been evaluated using western blotting, immunohistochemistry, and HuProt microarray specificity validation methods to support selective FABP1 detection in research applications. Western blot analysis commonly identifies FABP1 near its predicted molecular weight in intestinal and hepatic tissue lysates, while immunohistochemistry demonstrates strong cytoplasmic staining patterns consistent with the known biology of this fatty acid transport protein. Protein microarray validation further supports specificity for FABP1 among thousands of human proteins represented on the array.
For additional antibodies targeting metabolic signaling, lipid transport, nutrient sensing, and energy homeostasis pathways, explore our broader Metabolism Antibodies products featuring markers involved in hepatic, intestinal, adipocyte, and mitochondrial biology.
Optimal dilution of the FABP1 Antibody / Lipid Metabolism Marker Antibody should be determined by the researcher.
A portion of amino acids 1-127 from the human protein was used as the immunogen for the FABP1 antibody.
Store the FABP1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Fatty acid-binding protein 1 antibody, Liver fatty acid-binding protein antibody, L-FABP antibody, FABP1 lipid metabolism antibody, FABP1 liver marker antibody
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