F13A1 Antibody for IHC / Coagulation factor XIII A chain [clone MSVA-813R] (V6072)

F13A1 Antibody for IHC Tissue Microarray (TMA). Immunohistochemistry analysis of Coagulation factor XIII A chain F13A1 in formalin-fixed paraffin-embedded human normal and cancer tissue microarrays using recombinant rabbit monoclonal antibody clone MSVA-813R. Tissue microarray (TMA) staining with HRP-DAB brown chromogen demonstrates predominant cytoplasmic localization in scattered stromal and histiocytic cell populations, consistent with expression in dermal dendrocytes and macrophage-lineage cells, while most epithelial compartments remain largely negative. In normal tissue microarrays, positive cells are observed in skin, lymph node, and placenta. Within tumor tissue microarrays, cytoplasmic staining is present in subsets of fibrohistiocytic and macrophage-rich tumors, whereas many epithelial malignancies demonstrate absent or minimal labeling. Evaluation across large TMA panels enables direct comparison of F13A1 expression across diverse tissue types under standardized conditions. The observed staining patterns align with reported expression profiles in the Human Protein Atlas and support its use as a marker of dermal dendrocytes and macrophage-associated cells.