- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
ETF1 Antibody / eRF1 Antibody (FY13496)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY13496 | Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml | 100 ug | 449 |
|
| Species Reactivity | Human, Mouse, Rat |
| Format | Lyophilized |
| Host | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen Affinity |
| Buffer | Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3. |
| UniProt | P20132 |
| Applications | Western Blot : 0.5-1ug/ml |
| Limitations | This ETF1 Antibody / eRF1 Antibody is available for research use only. |
|
Review this product on BioCompare and get a $20 Amazon gift card
|
Related Products
|
ETF1 Antibody / eRF1 Antibody recognizes ETF1, the gene encoding eRF1 (eukaryotic release factor 1), the essential class I translation termination factor responsible for recognizing all three stop codons during eukaryotic protein synthesis. eRF1 functions together with the GTPase eRF3 to terminate translation by promoting hydrolysis of the peptidyl-tRNA bond within the ribosome, releasing the completed polypeptide chain. Because eRF1 recognizes the UAA, UAG, and UGA stop codons, it serves as the universal translation release factor in eukaryotic cells and is indispensable for accurate protein synthesis and maintenance of translational fidelity.
eRF1 is composed of functional domains that mediate stop codon recognition, interaction with the ribosomal decoding center, and catalysis of peptide release. Following stop codon recognition, eRF1 cooperates with eRF3 to coordinate GTP hydrolysis and efficient translation termination before ribosome recycling begins. Beyond its canonical role, eRF1 also participates in mRNA quality control pathways, including nonsense-mediated decay, and helps prevent translational readthrough that could otherwise produce aberrant or extended proteins. Through these mechanisms, ETF1 contributes to cellular protein homeostasis and maintenance of the proteome.
ETF1 is ubiquitously expressed because translation termination is required in every actively translating cell. Altered eRF1 expression or activity has been associated with changes in translational accuracy, stress responses, viral protein synthesis, neurodegenerative disorders, and cancer. The protein has also become an important target in therapeutic strategies designed to manipulate premature stop codon readthrough for the treatment of inherited genetic diseases. As interest in translational control continues to expand, eRF1 remains a central molecule for understanding how protein synthesis is completed with high accuracy and efficiency.
An ETF1 Antibody is a valuable tool for investigating eRF1 expression, translation termination, and ribosome-associated protein complexes in cultured cells and tissue specimens. Researchers frequently use eRF1 Antibody reagents to study protein synthesis, translational fidelity, stop codon recognition, mRNA surveillance, ribosome biology, and mechanisms that regulate translation termination.
Explore our Cancer Marker Antibodies page for additional proteins involved in translational control, cellular growth, and tumor biology.
Optimal dilution of the ETF1 Antibody / eRF1 Antibody should be determined by the researcher.
E.coli-derived human Eukaryotic peptide chain release factor subunit 1 recombinant protein (amino acids D9-K342) was used as the immunogen for the ETF1 Antibody.
After reconstitution, the ETF1 Antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
ETF1 Antibody, eRF1 Antibody, Eukaryotic Translation Termination Factor 1 Antibody, Eukaryotic Peptide Chain Release Factor 1 Antibody
Your bulk quote request has been submitted successfully!
Please contact us if you have any questions.
Powered by Bioz
