- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Estrogen receptor beta Antibody / ER beta [clone ESR2/9709] (V5881)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V5881-100UG | 0.2 mg/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide | 100 ug | 559 | |
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V5881-20UG | 0.2 mg/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide | 20 ug | 259 | |
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V5881SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | ESR2/9709 |
| UniProt | Q92731 |
| Localization | Nucleus |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This Estrogen receptor beta/ER beta antibody is available for research use only. |
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Estrogen receptor beta Antibody targets Estrogen receptor beta, a nuclear hormone receptor encoded by the ESR2 gene and also referred to as Estrogen receptor 2 in the literature. ER beta functions as a ligand-activated transcriptional regulator that modulates cellular responses to estrogen signaling, often acting in a regulatory or balancing role relative to Estrogen receptor alpha. Through context-dependent gene regulation, Estrogen receptor beta contributes to fine-tuning estrogen-responsive transcriptional programs across multiple tissues.
ER beta is primarily localized to the nucleus, where it binds estrogen response elements and interacts with transcriptional co-regulators to influence gene expression output. Unlike ER alpha, Estrogen receptor beta frequently participates in transcriptional modulation rather than strong transcriptional activation, shaping signaling outcomes through selective gene regulation. Estrogen receptor beta Antibody detection is therefore valuable for studying nuclear receptor signaling dynamics and estrogen-dependent transcriptional balance.
Functionally, Estrogen receptor beta regulates genes involved in cellular differentiation, growth restraint, immune signaling, and tissue homeostasis. ER beta expression is prominent in tissues such as ovary, prostate, lung, brain, and immune-associated cell populations, where estrogen signaling exerts nuanced regulatory effects. Estrogen receptor beta activity often counterbalances ER alpha-driven pathways, supporting coordinated estrogen signaling rather than unchecked transcriptional activation.
Alterations in Estrogen receptor beta expression or regulatory activity have been associated with disease-related changes in hormone responsiveness and cellular behavior. Dysregulated ER beta signaling can contribute to shifts in transcriptional programs affecting proliferation, differentiation, and inflammatory responses. Studying Estrogen receptor 2 at the level of ER beta-specific regulation provides insight into estrogen signaling mechanisms that extend beyond classical ER alpha biology.
Clone ESR2/9709 is designed to recognize Estrogen receptor beta in research applications. Estrogen receptor beta Antibody reagents are suitable for detecting nuclear ER beta expression and supporting studies focused on estrogen signaling balance, transcriptional regulation, and hormone-responsive gene expression control.
Optimal dilution of the Estrogen receptor beta/ER beta antibody should be determined by the researcher.
A recombinant fragment (around amino acids 1-200) of human ESR2 protein (exact sequence is proprietary) was used as the immunogen for the Estrogen receptor beta/ER beta antibody.
Estrogen receptor beta/ER beta antibody with sodium azide - store at 2 to 8oC; antibody without sodium azide - store at -20 to -80oC.
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