- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
ESR1 Antibody / Estrogen receptor 1 [clone rESR1/9525] (V5879)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V5879-100UG | 0.2 mg/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide | 100 ug | 559 | |
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V5879-20UG | 0.2 mg/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide | 20 ug | 259 | |
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V5879SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Recombinant Mouse Monoclonal |
| Isotype | Mouse IgG2b, kappa |
| Clone Name | rESR1/9525 |
| UniProt | P03372 |
| Localization | Nucleus |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml Western Blot : 2-4ug/ml |
| Limitations | This ESR1/Estrogen receptor 1 antibody is available for research use only. |
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ESR1 antibody targets Estrogen receptor 1, a nuclear hormone receptor encoded by the ESR1 gene that is also widely referred to as estrogen receptor alpha and ER alpha in the literature. Estrogen receptor 1 functions as a ligand-activated transcription factor that mediates cellular responses to estrogen by regulating gene expression programs involved in cell proliferation, differentiation, and tissue homeostasis. As a member of the steroid hormone receptor family, estrogen receptor alpha plays a central role in hormone-responsive tissues and endocrine signaling pathways.
Estrogen receptor 1 is primarily localized to the nucleus, where ER alpha binds estrogen response elements within target gene promoters following ligand activation. In addition to direct DNA binding, estrogen receptor alpha interacts with a range of transcriptional co-regulators and signaling proteins that fine-tune transcriptional output. ESR1 antibody detection is therefore widely used for studying nuclear receptor signaling and estrogen-dependent transcriptional regulation in tissue-based and cell-based research models.
Functionally, Estrogen receptor 1 regulates genes involved in reproductive tissue development, cell cycle control, and metabolic regulation. Estrogen receptor alpha activity is especially important in tissues such as breast, uterus, ovary, and bone, where estrogen signaling drives normal physiological function. ESR1 antibody reagents support investigations into hormone receptor biology, estrogen signaling dynamics, and transcriptional control mechanisms associated with ER alpha activity.
Altered expression or signaling of Estrogen receptor 1 has been linked to multiple disease states, particularly hormone-responsive cancers. Dysregulation of estrogen receptor alpha contributes to abnormal cellular proliferation and altered differentiation programs, making ESR1 a major focus of cancer biology and endocrine research. Changes in ER alpha expression patterns and signaling behavior have also been associated with disease progression and altered hormone responsiveness in experimental models.
Clone rESR1/9525 is designed to recognize Estrogen receptor 1 in research applications. ESR1 antibody reagents are suitable for detecting nuclear ER alpha expression in hormone-responsive tissues and experimental systems, supporting studies focused on estrogen signaling, transcriptional regulation, and disease-associated alterations in estrogen receptor activity.
Optimal dilution of the ESR1/Estrogen receptor 1 antibody should be determined by the researcher.
A recombinant fragment corresponding to C-terminus of human ESR1 protein (exact sequence is proprietary) was used as the immunogen for the ESR1/Estrogen receptor 1 antibody.
ESR1/Estrogen receptor 1 antibody with sodium azide - store at 2 to 8oC; antibody without sodium azide - store at -20 to -80oC.
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