- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
ERIS Antibody STING1/8187R / STING1 Rabbit Monoclonal Antibody [clone STING1/8187R] (V5101)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V5101-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
|
V5101-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
|
|
V5101SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | STING1/8187R |
| Purity | Protein A/G affinity |
| UniProt | Q86WV6 |
| Localization | Cytoplasm |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This ERIS antibody is available for research use only. |
|
Review this product on BioCompare and get a $20 Amazon gift card
|
Related Products
|
Stimulator of interferon genes protein (STING1), encoded by the STING1 gene and also known as TMEM173 or ERIS (endoplasmic reticulum interferon stimulator), is an intracellular adaptor protein that plays a central role in cytosolic DNA sensing and innate immune signaling. ERIS Antibody STING1/8187R recognizes STING1, a signaling protein localized primarily to the endoplasmic reticulum that functions as a critical mediator of interferon induction following detection of foreign or damaged DNA within the cytoplasm. STING1 acts as a key component of the cyclic GMP-AMP synthase (cGAS)-STING pathway, which detects cytosolic DNA derived from viral infection, bacterial pathogens, mitochondrial damage, or genomic instability.
When cyclic GMP-AMP synthase binds cytosolic DNA, it produces the cyclic dinucleotide cGAMP, which directly activates STING1. Activated STING undergoes conformational changes and traffics from the endoplasmic reticulum to Golgi-associated vesicular compartments where it recruits downstream kinases including TBK1 and transcription factors such as IRF3. This signaling cascade leads to the production of type I interferons and other inflammatory cytokines that form a critical component of innate immune defense against infection. STING signaling therefore links detection of abnormal cytoplasmic DNA to activation of antiviral and inflammatory immune responses.
STING1 is broadly expressed in immune cells including macrophages, dendritic cells, and lymphocytes, as well as in many epithelial and stromal cell types. Activation of the STING pathway contributes to host defense against viruses and intracellular pathogens, while dysregulation of STING signaling has been implicated in autoinflammatory diseases, autoimmune disorders, and cancer immunity. Because of its central role in innate immune signaling, STING1 is widely studied in immunology and inflammation research.
A recombinant rabbit monoclonal antibody such as clone STING1/8187R supports detection of STING1 protein in research applications examining innate immune signaling pathways. Antibodies recognizing STING1 enable investigation of the cGAS-STING pathway, analysis of interferon-mediated immune responses, and study of immune signaling mechanisms involved in host defense and inflammatory disease.
Optimal dilution of the ERIS Antibody STING1/8187R should be determined by the researcher.
A recombinant partial protein sequence (within amino acids 190-290) from the human protein was used as the immunogen for the ERIS antibody.
Aliquot the STING1/ERIS antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
STING antibody, STING1 antibody, TMEM173 antibody, Stimulator of interferon genes protein antibody, ERIS antibody
Your bulk quote request has been submitted successfully!
Please contact us if you have any questions.
Powered by Bioz
