- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
ERG Antibody / Endothelial and Prostate Cancer Marker Antibody [clone ERG/2107] (V8982)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V8982-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V8982-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V8982SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2b, kappa |
| Clone Name | ERG/2107 |
| Purity | Protein A/G affinity |
| UniProt | P11308 |
| Localization | Nucleus, cytoplasm |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This ERG Antibody / Endothelial and Prostate Cancer Marker Antibody is available for research use only. |
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ETS-related gene (ERG) is a member of the ETS family of transcription factors that regulate gene expression programs involved in vascular development, angiogenesis, and cellular differentiation. ERG is highly expressed in endothelial cells where it plays a central role in maintaining vascular integrity, regulating endothelial cell survival, and controlling genes associated with angiogenic signaling pathways. In normal physiology, ERG contributes to blood vessel stability and is a key regulator of endothelial identity across a wide range of tissues.
ERG antibody, also referred to as ETS-related gene antibody and ERG transcription factor antibody in the literature, recognizes a nuclear protein that is widely used as a marker of endothelial cells and vascular structures in tissue sections. ERG expression is typically localized to the nucleus, consistent with its role as a DNA-binding transcription factor, and this nuclear staining pattern is a defining feature in immunohistochemical analysis of vascular endothelium. In addition to vascular tissues, ERG is expressed in select hematopoietic cell populations, reflecting its broader role in lineage specification and transcriptional control. This antibody is part of a collection of Human Protein Microarray validated antibodies that have been screened for specificity across thousands of proteins.
This ERG Antibody / Endothelial and Prostate Cancer Marker Antibody (clone ERG/2107) is uniquely positioned for research involving both vascular biology and oncology, particularly in the context of prostate cancer. ERG is one of the most clinically relevant transcription factors in prostate cancer due to recurrent gene fusions, most commonly TMPRSS2-ERG, which drive aberrant ERG expression in tumor epithelial cells. These fusion events result in strong nuclear ERG staining in prostate carcinoma, making ERG a widely used biomarker for identifying prostate cancer and distinguishing it from benign or non-prostatic tissues. ERG expression in tumors is therefore a key indicator of oncogenic transcriptional reprogramming and disease progression.
In immunohistochemistry, ERG serves as a robust marker for endothelial cells, highlighting vascular networks within normal and tumor tissues, while also enabling detection of ERG-positive tumor nuclei in prostate cancer specimens. This dual utility supports studies of tumor angiogenesis, vascular remodeling, and cancer diagnostics. The clear nuclear localization of ERG staining provides strong contrast against surrounding stromal and epithelial compartments, facilitating accurate interpretation in complex tissue environments such as human tissue microarrays.
Microarray validation of clone ERG/2107 supports its specificity for the ERG protein, providing confidence in target recognition across diverse experimental settings. As a mouse monoclonal antibody, clone ERG/2107 offers consistent performance and reproducibility for detecting ERG expression in research applications. An ERG antibody is suitable for detecting ERG expression in vascular biology studies, cancer research, and tissue-based analyses where endothelial and tumor-associated expression patterns are of interest.
This antibody is part of a broader antibody panel offered by NSJ Bioreagents.
Optimal dilution of the ERG Antibody / Endothelial and Prostate Cancer Marker Antibody should be determined by the researcher.
Recombinant human full-length ERG protein was used as the immunogen for the ERG antibody.
Aliquot the ERG antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
ERG antibody, ETS-related gene antibody, ERG transcription factor antibody, ERG endothelial marker antibody, ERG prostate cancer marker antibody
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