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Home >> Antibodies >> ERBB4 Antibody (HER4)

ERBB4 Antibody (HER4) (R30981)

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  Catalog No Formulation Size Price (USD)  
Image R30981 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Western blot testing of ERBB4 antibody and Lane 1: human HeLa; 2: (h) U87; 3: mouse Neuro-2a cell lysate. Predicted molecular weight: 147-180kDa (precursor), 120, 80 kDa (cleaved forms). Observed here at ~147kDa.
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Western blot testing of ERBB4 antibody and Lane 1: human HeLa; 2: (h) U87; 3: mouse Neuro-2a cell lysate. Predicted molecular weight: 147-180kDa (precursor), 120, 80 kDa (cleaved forms). Observed here at ~147kDa.
Western blot testing of ERBB4 antibody and Lane 1: A549; 2: HeLa cell lysate. Predicted molecular weight: 147-180kDa (precursor), 120, 80 kDa (cleaved forms). Observed here at ~147kDa.
Western blot testing of ERBB4 antibody and Lane 1: Recombinant human partial protein 10ng; 2: 5ng; 3: 2.5ng; 4: 1.25ng
Availability 1-3 business days
Species Reactivity Human, Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
UniProt Q15303
Applications Western blot : 0.5-1ug/ml
Limitations This ERBB4 antibody is available for research use only.
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Description

V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4, also known as HER4, is an enzyme that in humans is encoded by the ERBB4 gene. The HER4/ERBB4 gene is a member of the type I receptor tyrosine kinase subfamily that includes EGFR, ERBB2 and ERBB3. ERBB4 is a single-pass type I transmembrane protein with multiplefurin-like cysteine rich domains, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and aPDZ domainbinding motif.Huang et al.(2000) reported that the proteinis enriched in the postsynaptic density and associates with PSD95. Itis a transmembrane receptor tyrosine kinase that regulates cell proliferation and differentiation. After binding its ligand, heregulin, or activation of protein kinase C by TPA, the ERBB4 ectodomain is cleaved by a metalloprotease. Ni et al.(2001)concluded that gamma-secretase cleavage ofthe proteinmay represent another mechanism for receptor tyrosine kinase-mediated signaling.

Application Notes

The stated application concentrations are suggested starting amounts. Titration of the ERBB4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

An amino acid sequence from the N-terminus of human ErbB4/HER4 (KLSSLSDLEQQYRALRK) was used as the immunogen for this ERBB4 antibody (100% homologous in human, mouse and rat).

Storage

After reconstitution, the ERBB4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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