- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
ER alpha Antibody / Estrogen receptor alpha [clone IE-5] (RQ5022)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
RQ5022 | Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA | 100 ul | 449 |
| Availability | 1-2 weeks |
| Species Reactivity | Human, Mouse, Rat |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Clone Name | IE-5 |
| Purity | Affinity purified |
| UniProt | P03372 |
| Applications | Western Blot : 1:500-1:2000 Immunohistochemistry (FFPE) : 1:50-1:100 Immunofluorescence : 1:50-1:100 |
| Limitations | This ER alpha antibody is available for research use only. |
|
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ER alpha antibody targets Estrogen receptor alpha, a ligand-responsive nuclear regulatory protein that mediates cellular responses to estrogen signaling. ER alpha represents the functionally dominant estrogen receptor isoform in many hormone-responsive tissues and acts as a transcriptional regulator that integrates hormonal cues with gene expression programs controlling cellular growth, differentiation, and tissue organization. Detection of ER alpha is therefore central to studies of estrogen-driven biological processes.
ER alpha localizes primarily to the nucleus, where it regulates transcription through direct interaction with estrogen response elements as well as through tethering mechanisms involving other transcription factors. In addition to classical genomic signaling, ER alpha participates in dynamic regulatory networks that influence chromatin structure and transcriptional responsiveness. ER alpha antibody reagents are useful for examining nuclear receptor localization and estrogen-dependent transcriptional regulation in tissue-based research systems.
Functionally, ER alpha activity shapes gene expression programs involved in epithelial cell differentiation, reproductive tissue maintenance, and hormone-regulated metabolic processes. Its regulatory influence is particularly prominent in breast, uterine, and ovarian tissues, where estrogen signaling drives coordinated transcriptional responses. ER alpha antibody detection supports investigations into hormone receptor biology, transcriptional regulation, and estrogen-responsive cellular states.
Alterations in ER alpha expression or regulatory activity are associated with disease-related changes in hormone responsiveness. Dysregulated ER alpha signaling contributes to abnormal transcriptional programs that affect cellular proliferation and differentiation, making ER alpha a key research focus in hormone-driven disease models. Changes in ER alpha expression patterns have also been linked to shifts in cellular sensitivity to estrogen signaling cues.
ER alpha antibody reagents are suitable for detecting nuclear Estrogen receptor alpha expression in research applications. These antibodies support studies focused on estrogen signaling pathways, transcriptional regulation, hormone receptor dynamics, and disease-associated alterations in estrogen-responsive gene expression.
Optimal dilution of the ER alpha antibody should be determined by the researcher.
A synthetic peptide specific to human ER alpha / ESR1 was used as the immunogen for the ER alpha antibody.
Store the ER alpha antibody at -20oC.
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