- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
ER alpha Antibody Rabbit Monoclonal / Estrogen Receptor alpha [clone ESR1/7444R] (V5169)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V5169-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V5169-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V5169SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | ESR1/7444R |
| Purity | Protein A/G affinity |
| UniProt | P03372 |
| Localization | Nucleus |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This ER alpha antibody is available for research use only. |
|
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ER alpha Antibody Rabbit Monoclonal clone ESR1/7444R recognizes Estrogen Receptor alpha, a ligand-activated nuclear transcription factor encoded by the ESR1 gene on chromosome 6q25.1. Estrogen Receptor alpha, also commonly referred to as ER alpha, ER-A, or ESR1 antibody target protein, belongs to the nuclear receptor superfamily and plays a central role in regulating gene expression in response to estrogen signaling. ER alpha Antibody Rabbit Monoclonal Clone ESR1/7444R targets ER alpha protein for research applications involving hormone receptor biology and endocrine-related disease investigation.
Estrogen Receptor alpha contains a conserved DNA-binding domain composed of zinc finger motifs, a ligand-binding domain responsible for estrogen recognition, and activation function domains that coordinate transcriptional regulation. Upon binding its ligand, ESR1 undergoes structural rearrangement that promotes receptor dimerization and nuclear localization. The activated receptor binds estrogen response elements within promoter regions of target genes and recruits transcriptional coactivators or corepressors, thereby modulating gene networks involved in cellular proliferation, differentiation, and survival.
ER alpha expression is most prominent in breast epithelium, endometrium, ovary, and additional hormone-responsive tissues. In oncology research, ESR1 expression is a widely studied biomarker in breast carcinoma and other estrogen-dependent malignancies. Alterations in ESR1 signaling, including gene amplification, splice variants, or activating mutations, can influence tumor growth behavior and endocrine responsiveness. Beyond oncology, ER alpha also contributes to bone metabolism, cardiovascular regulation, metabolic balance, and neuroendocrine signaling pathways.
ER alpha Antibody Rabbit Monoclonal clone ESR1/7444R enables investigation of ESR1 localization and expression in cellular and tissue-based research models. By targeting Estrogen Receptor alpha protein, this antibody supports studies focused on estrogen-driven transcriptional programs and hormone-dependent disease mechanisms. Detection of ER alpha remains fundamental to research exploring endocrine regulation in normal physiology and pathological contexts.
Optimal dilution of the ER alpha antibody should be determined by the researcher.
A recombinant partial protein sequence (within amino acids 495-595) from the human protein was used as the immunogen for the ER alpha antibody rabbit monoclonal ESR1/7444R.
Aliquot the ER alpha antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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