- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
ER-A Antibody Recombinant Rabbit MAb / Estrogen Receptor alpha [clone ESR1/8407R] (V5192)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V5192-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
|
V5192-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
|
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V5192SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | ESR1/8407R |
| Purity | Protein A/G affinity |
| UniProt | P03372 |
| Localization | Nucleus |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This ER-A antibody is available for research use only. |
|
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ER-A Antibody Recombinant Rabbit MAb ESR1/8407R recognizes Estrogen Receptor alpha, a ligand-activated nuclear hormone receptor encoded by the ESR1 gene on chromosome 6q25.1. Estrogen Receptor alpha, commonly referred to as ER alpha or ER-A in the literature, is a member of the nuclear receptor superfamily and functions as a transcription factor regulating genes involved in cell proliferation, differentiation, and hormone-responsive signaling pathways. This recombinant rabbit monoclonal antibody targets ER alpha protein in research applications involving hormone receptor biology.
Estrogen Receptor alpha contains several functional domains, including a DNA-binding domain with zinc finger motifs, a ligand-binding domain, and activation function regions that coordinate transcriptional regulation. Upon binding estrogen, ESR1 undergoes conformational changes that promote receptor dimerization, nuclear localization, and recruitment of transcriptional coactivators or corepressors. These molecular interactions enable regulation of genes controlling growth, survival, and differentiation in estrogen-responsive tissues.
Expression of ER alpha is most prominent in breast epithelium, endometrium, ovary, and other reproductive tissues. In oncology research, ESR1 expression status is a central biomarker in breast carcinoma and other hormone-dependent malignancies. Alterations in ESR1 signaling, amplification, or mutation can influence tumor growth behavior and endocrine responsiveness. Beyond oncology, ER alpha also participates in bone metabolism, cardiovascular biology, and neuroendocrine regulation.
The recombinant format of clone ESR1/8407R supports consistency between production lots while targeting Estrogen Receptor alpha protein in research settings. ER-A Antibody Recombinant Rabbit MAb ESR1/8407R enables investigation of ESR1 distribution and expression in cellular and tissue-based studies focused on estrogen signaling pathways and hormone-driven disease models.
Optimal dilution of the ER-A antibody should be determined by the researcher.
A recombinant partial protein sequence (within amino acids 495-595) from the human protein was used as the immunogen for the ER-A antibody recombinant rabbit mAb ESR1/8407R.
Aliquot the ER-A antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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