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Home >> Antibodies >> EPR1 Antibody

EPR1 Antibody (F40075)

  Catalog No Formulation Size Price (USD)  
Image F40075-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 369
Image
F40075-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 155
EPR1 antibody used in western blot to detect EPR1 in HL-60 cell lysate
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Purified
UniProt Q14868
Applications Western blot : 1:1000
Limitations This EPR1 antibody is available for research use only.
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Description

Cellular receptors for blood proteases regulate chemotaxis, extracellular proteolysis, and growth behavior of normal and malignant cells. Effector cell protease receptor-1 (EPR1) is a receptor for the coagulation protease factor Xa. EPR1 is characterized by a cysteine-rich extracellular module, a single membrane-spanning domain, and a serine-rich cytoplasmic tail featuring at least 15 potential phosphorylation sites. EPR1 also contains 2 N-linked glycosylation sites, 4 O-linked glycosylation sites, and a chondroitin sulfate attachment site, which may provide anchoring for carbohydrate chains, EPR1 transfectants bind to factor Xa in a specific and saturable manner, and in the absence of factor V/Va promote prothrombin activation in a factor Xa concentration-dependent reaction. Activated platelets and megakaryocytes express EPR1. Both EPR1 and membrane-bound factor Va are thought to be required to mediate factor Xa binding to the activated platelet to form a functional prothrombinase complex.

Application Notes

Titration of the EPR1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 308-337 from the human protein was used as the immunogen for this EPR1 antibody.

Storage

Aliquot the EPR1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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