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Home >> Antibodies >> EPO Receptor Antibody

EPO Receptor Antibody (RQ4024)

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Image RQ4024 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Western blot testing of rat lung tissue with EPO Receptor antibody at 0.5ug/ml. Predicted molecular weight ~55 kDa (memebrane bound form), ~29 kDa (soluble form).
Western blot testing of rat lung tissue with EPO Receptor antibody at 0.5ug/ml. Predicted molecular weight ~55 kDa (memebrane bound form), ~29 kDa (soluble form).
Availability 1-3 business days
Species Reactivity Human, Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity purified
Buffer Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
UniProt P19235
Applications Western Blot : 0.5-1ug/ml
Direct ELISA : 0.1-0.5ug/ml
Limitations This EPO Receptor antibody is available for research use only.
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Description

The erythropoietin receptor (EpoR) is a protein that in humans is encoded by the EPOR gene. This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.

Application Notes

Optimal dilution of the EPO Receptor antibody should be determined by the researcher.

Immunogen

A recombinant human partial protein corresponding to amino acids E48-E226 was used as the immunogen for the EPO Receptor antibody.

Storage

After reconstitution, the EPO Receptor antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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