- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Epidermal Growth Factor Receptor Antibody / EGFR [clone EGFR/8933R] (V5197)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V5197-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V5197-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V5197SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | EGFR/8933R |
| Purity | Protein A/G affinity |
| UniProt | P00533 |
| Localization | Cell Surface |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT Western Blot : 2-4ug/ml |
| Limitations | This Epidermal Growth Factor Receptor antibody is available for research use only. |
|
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Epidermal Growth Factor Receptor Antibody recognizes Epidermal growth factor receptor, a transmembrane receptor tyrosine kinase that plays a central role in regulating cell proliferation, survival, migration, and differentiation. EGFR is a member of the ErbB receptor family and is activated through ligand binding followed by receptor dimerization and autophosphorylation of intracellular tyrosine residues. Epidermal Growth Factor Receptor Antibody is widely used in research settings to evaluate EGFR expression patterns and signaling activity in epithelial-derived tissues and disease models.
Epidermal growth factor receptor is encoded by the EGFR gene and is predominantly localized to the cell membrane, with ligand-induced internalization into endosomal compartments following activation. It is broadly expressed in epithelial tissues including skin, lung, gastrointestinal tract, and glandular epithelia. Tight regulation of EGFR signaling is required for normal tissue homeostasis, as excessive or prolonged activation can drive abnormal cell growth and survival signaling pathways.
Dysregulation of EGFR expression or signaling is strongly associated with oncogenic transformation and tumor progression. Overexpression, amplification, or activating mutations of EGFR have been documented in multiple cancer types, including carcinomas of the lung, colon, head and neck, and skin. Because of this, Epidermal Growth Factor Receptor Antibody is frequently applied in cancer biology research to study receptor abundance, cellular localization, and pathway activation in tumor versus normal tissues.
Beyond oncology, EGFR also contributes to wound healing, epithelial regeneration, and developmental signaling processes. Epidermal Growth Factor Receptor Antibody supports investigations into receptor-mediated signaling cascades such as MAPK, PI3K-AKT, and JAK-STAT pathways, enabling detailed analysis of EGFR biology in both physiological and pathological research applications.
Optimal dilution of the Epidermal Growth Factor Receptor antibody should be determined by the researcher.
A recombinant partial protein sequence (within amino acids 300-500) from the human protein was used as the immunogen for the Epidermal Growth Factor Receptor antibody.
Aliquot the Epidermal Growth Factor Receptor antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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