- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
EpCAM Antibody [clone Ber-EP4] (V7934)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V7934-0.5ML | Culture supernatant with 0.05% sodium azide | 0.5 ml | 539 | |
|
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V7934-0.1ML | Culture supernatant with 0.05% sodium azide | 0.1 ml | 249 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Culture supernatant |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | Ber-EP4 |
| Purity | Culture supernatant |
| UniProt | P16422 |
| Localization | Cell surface, cytoplasmic |
| Applications | Immunohistochemistry (FFPE) : 1:100-1:200 Flow Cytometry : 1:100-1:200 |
| Limitations | This EpCAM antibody is available for research use only. |
|
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EpCAM antibody detects epithelial cell adhesion molecule, encoded by the EPCAM gene. EpCAM is a transmembrane glycoprotein expressed broadly on epithelial tissues and frequently overexpressed in epithelial-derived tumors. It mediates intercellular adhesion, modulates signaling pathways, and contributes to proliferation and migration. Because EpCAM is widely recognized as a carcinoma-associated marker, EpCAM antibody is extensively used in pathology, oncology, and epithelial biology.
EpCAM has a large extracellular region, a transmembrane domain, and a short intracellular tail. Beyond adhesion, it undergoes regulated proteolysis, releasing intracellular fragments that influence gene transcription and cell survival. Overexpression of EpCAM in many carcinomas correlates with poor prognosis, highlighting its role in cancer progression and metastasis. Its surface localization makes it accessible for both detection and therapeutic targeting.
The EpCAM antibody clone Ber-EP4 provides robust and reproducible recognition of this marker. Clone Ber-EP4 has been referenced extensively in peer-reviewed publications and is widely used in diagnostic pathology. It reliably distinguishes epithelial-derived carcinomas from mesotheliomas and non-epithelial malignancies. In cytology, clone Ber-EP4 is employed to identify carcinoma cells in effusions and fine-needle aspirates, supporting accurate diagnosis and classification.
Research using clone Ber-EP4 has shown its diagnostic importance across cancers such as lung, breast, colorectal, and ovarian carcinoma. It has also been applied in studies of circulating tumor cells, where EpCAM detection enables enrichment and analysis of malignant cells in blood. Beyond oncology, this antibody supports basic epithelial biology research, providing insight into cell polarity, adhesion, and differentiation pathways.
NSJ Bioreagents provides this EpCAM antibody to support oncology, epithelial biology, and diagnostic research. Alternate names include EPCAM antibody, ESA antibody, TACSTD1 antibody, tumor-associated calcium signal transducer 1 antibody, epithelial tumor marker antibody, and Ber-EP4 antibody.
Optimal dilution of the EpCAM antibody should be determined by the researcher.
Human breast cancer MCF-7 cells were used as the immunogen for the EpCAM antibody.
Store the EpCAM antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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