- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
EpCAM Antibody [clone Ber-EP4] (V5762)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V5762-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 539 | |
|
|
V5762-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 249 | |
|
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V5762SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 539 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | Ber-EP4 |
| Purity | Protein G affinity |
| UniProt | P16422 |
| Localization | Cell surface, cytoplasmic |
| Applications | Flow Cytometry : 1-2ug/million cells Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This EpCAM antibody is available for research use only. |
|
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EpCAM antibody detects epithelial cell adhesion molecule, encoded by the EPCAM gene, using the Ber-EP4 clone. EpCAM is a transmembrane glycoprotein expressed on most epithelial cells and many epithelial-derived tumors. It mediates intercellular adhesion, promotes proliferation, and contributes to signaling pathways that regulate epithelial growth. Because of its strong expression in carcinomas, EpCAM antibody is extensively used in diagnostic pathology and cancer biology.
EpCAM consists of an extracellular domain responsible for adhesion, a single transmembrane region, and a short cytoplasmic tail involved in signal transduction. Beyond structural roles, EpCAM undergoes regulated intramembrane proteolysis, releasing an intracellular fragment that enters the nucleus to influence transcription. This activity supports proliferation and survival, making EpCAM both a marker and a functional driver in carcinogenesis.
The EpCAM antibody clone Ber-EP4 is well established in pathology and has been widely cited in peer-reviewed publications. It provides reliable detection in differentiating carcinomas from mesotheliomas and other non-epithelial tumors. Its diagnostic utility extends to identifying metastatic carcinoma in effusions and fine-needle aspirates, where Ber-EP4 positivity helps confirm epithelial origin. This clone has become a standard tool in surgical pathology laboratories worldwide.
Research using clone Ber-EP4 has clarified how EpCAM expression correlates with tumor aggressiveness and prognosis in cancers such as breast, colon, and ovarian carcinoma. The antibody has also been employed in studies of circulating tumor cells, where EpCAM detection enables enrichment and characterization of malignant cells in peripheral blood. Beyond oncology, Ber-EP4 assists in basic epithelial biology, where EpCAM expression helps map differentiation and lineage specification.
NSJ Bioreagents supplies this EpCAM antibody to support oncology, pathology, and epithelial biology. Alternate names include epithelial cell adhesion molecule antibody, ESA antibody, TACSTD1 antibody, tumor-associated calcium signal transducer 1 antibody, epithelial tumor marker antibody, and Ber-EP4 antibody.
Optimal dilution of the EpCAM antibody should be determined by the researcher.
Human breast cancer MCF-7 cells were used as the immunogen for the EpCAM antibody.
Aliquot the EpCAM antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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