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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Eotaxin 3 Antibody C Terminus / CCL26 Antibody (R30523)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
R30523 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 449 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Antigen affinity purified |
| Host | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity |
| Buffer | Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal |
| UniProt | Q9Y258 |
| Applications | Western Blot : 0.5-1ug/ml |
| Limitations | This Eotaxin 3 antibody is available for research use only. |
|
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C-C motif chemokine ligand 26 (CCL26), commonly known as Eotaxin-3, is a secreted chemokine that plays a key role in immune cell recruitment during inflammatory responses. As a member of the CC chemokine family, the protein functions primarily as a chemoattractant for eosinophils through interaction with the chemokine receptor CCR3. Eotaxin 3 Antibody C Terminus recognizes the carboxyl-terminal portion of the CCL26 protein and enables detection of Eotaxin-3 expression in studies investigating allergic inflammation, immune signaling, and cytokine-mediated immune cell recruitment.
Antibodies directed against the carboxyl-terminal region of this chemokine are frequently described in the literature as Eotaxin 3 C-terminal antibody, Eotaxin 3 C-terminus antibody, or CCL26 C-terminal antibody, reflecting recognition of the C-terminal domain of the Eotaxin-3 protein. Detection of the C-terminus can be useful for studies investigating chemokine processing, secretion, and extracellular signaling events because secreted chemokines often undergo cleavage or modification after synthesis. A C-terminal Eotaxin 3 antibody therefore provides a useful tool for studying chemokine structure, processing, and receptor interaction dynamics.
Eotaxin-3 is produced by several cell types including epithelial cells, endothelial cells, fibroblasts, and smooth muscle cells in response to inflammatory cytokines such as interleukin-4 and interleukin-13. The chemokine participates in type 2 immune responses by recruiting eosinophils to sites of inflammation. Increased expression of CCL26 has been reported in allergic inflammatory conditions including asthma, allergic rhinitis, and eosinophilic gastrointestinal disorders. Because of this role in eosinophil recruitment, detection of Eotaxin-3 expression is widely used in studies examining allergic inflammation and immune cell migration.
Expression of CCL26 has also been investigated in epithelial tissues and tumor microenvironments where inflammatory cytokine signaling may induce chemokine production. In these contexts, Eotaxin-3 can contribute to immune cell recruitment within the tumor microenvironment and influence inflammatory signaling networks in epithelial cancers. Detection using an Eotaxin 3 antibody supports research examining chemokine regulation, cytokine signaling pathways, and inflammatory responses in epithelial and immune tissues.
This rabbit polyclonal antibody recognizes the C-terminal region of Eotaxin-3 / CCL26. An Eotaxin 3 antibody targeting the C-terminus supports studies investigating chemokine secretion, immune signaling mechanisms, and expression patterns of CCL26 in inflammatory and epithelial tissue environments.
The stated application concentrations are suggested starting amounts. Titration of the Eotaxin 3 Antibody C Terminus may be required due to differences in protocols and secondary/substrate sensitivity.
An amino acid sequence from the C-terminus of human Eotaxin 3 (CTHPRKKWVQKYISLLKTPKQL) was used as the immunogen for this Eotaxin 3 antibody.
After reconstitution, the Eotaxin 3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
CCL26 antibody, Eotaxin-3 antibody, Eotaxin 3 C-terminal antibody, C-C motif chemokine ligand 26 antibody
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