- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Eosinophil Peroxidase Antibody Clone EPO14 / EPX Antibody [clone EPO104] (V2303)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V2303-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
|
|
V2303-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
|
|
V2303SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
|
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | EPO104 |
| Purity | Protein G affinity chromatography |
| Buffer | 1X PBS, pH 7.4 |
| Gene ID | 8288 (Human) |
| Localization | Cytoplasmic, granular |
| Applications | Flow Cytometry : 0.5-1ug/million cells Immunofluorescence : 0.5-1ug/ml |
| Limitations | This Eosinophil Peroxidase antibody is available for research use only. |
|
Review this product on BioCompare and get a $20 Amazon gift card
|
Related Products
|
Eosinophil peroxidase (EPX) is a heme-containing enzyme predominantly expressed in eosinophils and stored within cytoplasmic secondary granules, where it plays a central role in host defense and inflammatory responses. Eosinophil Peroxidase Antibody Clone EPO104 / EPX Antibody is designed to detect this granule-associated protein, enabling precise identification of eosinophil lineage cells and characterization of eosinophil-driven immune responses in tissue samples.
Eosinophil peroxidase antibody, also referred to as EPX antibody or EPO antibody, recognizes a major constituent of eosinophil granules that is released during degranulation and immune activation. EPX catalyzes oxidative reactions that contribute to antimicrobial activity and modulation of inflammatory signaling, making it both a structural and functional marker of eosinophil activity. Its expression is largely restricted to eosinophils, providing high specificity for distinguishing these cells from other leukocyte populations.
Clone EPO104 antibody targets Eosinophil peroxidase with specificity for eosinophil granule content, producing a distinct granular cytoplasmic staining pattern that reflects the dense packaging of EPX within secretory granules. This pattern enables clear discrimination of eosinophils from neutrophils, lymphocytes, and monocytes, which lack comparable EPX expression. The granular localization also provides strong morphological confirmation of eosinophil identity, particularly in tissues with mixed inflammatory infiltrates.
Eosinophils play important roles in allergic inflammation, asthma, parasitic infections, and eosinophil-associated disorders such as eosinophilic esophagitis. Detection of EPX using Eosinophil Peroxidase Antibody Clone EPO104 enables visualization of eosinophil infiltration, spatial distribution, and density within affected tissues. This supports analysis of immune cell recruitment and provides insight into disease-associated inflammatory microenvironments.
Beyond host defense, EPX contributes to tissue remodeling and injury through the generation of reactive oxygen species and interaction with extracellular matrix components. Its release during eosinophil activation can influence epithelial cells, fibroblasts, and immune signaling pathways, linking EPX expression to both protective immune responses and pathological tissue changes. As a result, EPX serves as a functional indicator of eosinophil activation as well as a lineage marker.
Eosinophil Peroxidase Antibody clone EPO104 enables reliable detection of EPX with strong granular cytoplasmic staining and minimal background signal. The consistent staining pattern and clear cellular specificity of clone EPO104 antibody make it well suited for research applications focused on eosinophil biology, immune cell identification, inflammatory disease mechanisms, and characterization of eosinophil-rich tissue responses.
The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the Eosinophil Peroxidase Antibody Clone EPO14 to be titered up or down for optimal performance.
Human eosinophils from a patient with hypereosinophilic syndrome were used as the immunogen for this Eosinophil Peroxidase Antibody Clone EPO14.
Store the Eosinophil Peroxidase antibody at 2-8oC.
EPX antibody, Eosinophil peroxidase antibody, EPO antibody, EPX clone EPO104 antibody, Eosinophil granule protein antibody
Your bulk quote request has been submitted successfully!
Please contact us if you have any questions.
Powered by Bioz
Citations(6)