- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
ENDOD1 Antibody / Endonuclease domain-containing 1 protein Antibody targets ENDOD1, a protein with an endonuclease-related domain that has been implicated in cellular responses to DNA damage. Genome maintenance depends on coordinated recognition and processing of DNA lesions generated during replication, oxidative stress, and exposure to damaging agents. Proteins with nuclease-like domains can contribute to these pathways, although the presence of such a domain does not establish a particular physiological DNA substrate.
ENDOD1 has attracted interest because experimental perturbation of its expression can affect cellular survival in genetic backgrounds with compromised DNA repair. Studies have described synthetic-lethal relationships between ENDOD1 deficiency and defects in homologous recombination-associated pathways, including contexts involving BRCA1 or BRCA2. Synthetic lethality occurs when simultaneous disruption of two functions compromises viability even though loss of either function alone may be tolerated. Such relationships can reveal previously unrecognized dependencies within the networks that preserve genome integrity.
The molecular basis of ENDOD1-associated DNA repair phenotypes remains an important question. Cellular DNA damage responses involve nucleases, helicases, polymerases, checkpoint proteins, and chromatin regulators whose activities are tightly coordinated in time and space. A phenotype caused by ENDOD1 depletion may therefore reflect direct processing of nucleic acids, altered recruitment of repair factors, or an indirect consequence of disrupted cellular regulation. Defining endogenous substrates and catalytic requirements is necessary to distinguish among these possibilities.
NSJ Bioreagents offers this ENDOD1 Antibody to support research into ENDOD1 expression and its connections to DNA repair dependencies. A clearer understanding of how ENDOD1 contributes to cellular tolerance of genomic lesions could illuminate vulnerabilities that emerge when established repair pathways are impaired.
Explore related research targets in our Cell Biology Antibodies collection.
Optimal working dilutions for the ENDOD1 Antibody / Endonuclease domain-containing 1 protein Antibody should be established experimentally for each assay.
The ENDOD1 Antibody was generated using e. coli-derived human ENDOD1 recombinant protein (amino acids A49-K300).
After reconstitution, keep the ENDOD1 Antibody at 4oC for up to one month. Alternatively, store aliquots at -20oC for up to six months. Avoid multiple freezing and thawing cycles.
ENDOD1 antibody, Endonuclease domain-containing 1 protein antibody, endonuclease domain containing 1 antibody, KIAA0830 antibody, EC 3.1.30.- antibody, ENDOD1 rabbit polyclonal antibody
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