- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
EMC2 Antibody / ER membrane protein complex subunit 2 Antibody targets EMC2, a soluble core component of the endoplasmic reticulum membrane protein complex (EMC). The EMC is a conserved multiprotein assembly that supports the biogenesis of selected membrane proteins. Insertion of transmembrane segments into the ER membrane is a demanding process because hydrophobic helices must be transferred from the aqueous environment into the lipid bilayer while preserving their correct orientation. The EMC contributes to this process for particular classes of membrane proteins, complementing other insertion and translocation pathways.
EMC2 forms part of the cytosolic structural framework of the complex and helps organize interactions among EMC subunits. Structural studies have revealed a membrane-embedded region involved in accommodating hydrophobic segments and a cytosolic region that contributes to complex architecture. The EMC has been implicated in the insertion of terminal transmembrane helices and the biogenesis of certain multipass membrane proteins. Not every membrane protein depends equally on this machinery; reliance on EMC can reflect features such as transmembrane helix hydrophobicity and topology. This substrate selectivity is a key aspect of its biological function.
Proper membrane protein biogenesis is essential for receptors, transporters, and enzymes whose activities depend on correct membrane integration. When insertion fails, proteins may misfold, become unstable, or be diverted into quality-control pathways. Disrupting EMC components can therefore have downstream effects on cellular signaling and membrane physiology even when the complex itself does not directly carry out those functions. NSJ Bioreagents offers this EMC2 Antibody to support research into EMC assembly and the molecular basis of selective ER membrane protein insertion. Understanding the structural role of EMC2 may help explain how the complex coordinates cytosolic substrate handling with events occurring inside the lipid bilayer.
Explore related research targets in our Cell Biology Antibodies collection.
Users should optimize the working dilution of the EMC2 Antibody / ER membrane protein complex subunit 2 Antibody for their specific experimental setup.
The EMC2 Antibody was generated using e. coli-derived human TTC35/EMC2 recombinant protein (amino acids M1-S297).
Following reconstitution, the EMC2 Antibody can be kept at 4oC for one month. Aliquot for extended storage at -20oC for up to six months, avoiding repeated freezing and thawing.
EMC2 antibody, ER membrane protein complex subunit 2 antibody, KIAA0103 antibody, TPR repeat protein 35 antibody, EMC2 rabbit polyclonal antibody
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