- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Elastin Antibody / ELN [clone ELN/2069] (V8464)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V8464-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
|
|
V8464-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
|
|
V8464SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | ELN/2069 |
| Purity | Protein G affinity chromatography |
| UniProt | P15502 |
| Localization | Secreted |
| Applications | ELISA : order Ab without BSA for coating Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This Elastin antibody is available for research use only. |
|
Review this product on BioCompare and get a $20 Amazon gift card
|
Related Products
|
Elastin antibody targets Elastin, an insoluble extracellular matrix protein encoded by the ELN gene that forms the core of elastic fibers in connective tissues. Elastin is essential for providing reversible elasticity to tissues subjected to repeated mechanical strain, such as large arteries, lung parenchyma, dermis, and ligamentous structures. Unlike many structural proteins, Elastin is highly stable and persists for decades in mature tissues, underscoring its importance in long-term tissue mechanics.
Elastin is produced as the soluble monomer tropoelastin, which is secreted by fibroblasts, smooth muscle cells, and other mesenchymal cells before undergoing extensive cross-linking in the extracellular space. This cross-linking process generates a durable elastic network integrated with microfibrillar scaffolds composed of fibrillins and associated proteins. ELN antibody detection is therefore valuable for examining elastic fiber assembly, extracellular matrix architecture, and connective tissue organization.
From a functional perspective, Elastin enables tissues to store and release mechanical energy efficiently, allowing blood vessels to buffer pulsatile flow and lungs to recoil during respiration. Disruption of elastin fiber formation or accelerated elastin degradation compromises tissue compliance and contributes to progressive structural damage. ELN antibody reagents support studies focused on tissue biomechanics, extracellular matrix turnover, and age-related structural changes.
Alterations in Elastin distribution and integrity are implicated in a wide range of pathological processes. Reduced or fragmented elastin is characteristic of emphysema, vascular aneurysms, and fibrotic remodeling, while inherited ELN mutations cause connective tissue disorders such as supravalvular aortic stenosis and Williams syndrome. In oncology, elastin remodeling within the tumor stroma reflects changes in vascular architecture and stromal composition. These features make Elastin antibody-based detection relevant for cardiovascular, pulmonary, developmental, and cancer research.
Clone ELN/2069 is designed to recognize Elastin in research applications. Elastin antibody reagents are suitable for detecting elastic fiber distribution and extracellular matrix patterns in normal and diseased tissues, supporting investigations into connective tissue development, vascular remodeling, and disease-associated alterations in tissue elasticity.
Optimal dilution of the Elastin antibody should be determined by the researcher.
Recombinant full-length human Elastin protein was used as the immunogen for the Elastin antibody.
Store the Elastin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Your bulk quote request has been submitted successfully!
Please contact us if you have any questions.
Powered by Bioz
