- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
eIF-3 p48 Antibody / INT6 Antibody [clone 10F5H6] (RQ6979)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
RQ6979 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 449 |
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse, Rat |
| Format | Antigen affinity purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2b |
| Clone Name | 10F5H6 |
| Purity | Antigen affinity purified |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| UniProt | P60228 |
| Applications | Western Blot : 0.5-1 ug/ml Flow Cytometry : 1-3ug/million cells |
| Limitations | This eIF-3 p48 Antibody / INT6 Antibody is available for research use only. |
|
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eIF-3 p48 Antibody recognizes the protein historically known as eIF-3 p48, now designated EIF3E and also widely referred to as INT6. This protein is an essential component of the eukaryotic translation initiation factor 3 complex, where it contributes to the recruitment of messenger RNA and assembly of the translation pre-initiation complex during protein synthesis. Because eIF-3 p48 participates in both translational regulation and broader cellular signaling pathways, it has become an important target for studies of cell growth, differentiation, and disease. NSJ Bioreagents provides eIF-3 p48 Antibody for reliable detection of this multifunctional protein in diverse research applications.
The name INT6 originated from its identification as a common integration site for mouse mammary tumor virus, leading to early recognition of its association with tumor development. Subsequent research established that INT6 and EIF3E are the same protein and demonstrated its role within the eIF3 translation initiation complex. Beyond protein synthesis, EIF3E has been implicated in proteasome regulation, DNA damage responses, cell cycle progression, and maintenance of cellular homeostasis. These diverse functions have made eIF-3 p48 Antibody a valuable reagent for investigating the relationship between translational control and cellular physiology.
Altered expression or regulation of EIF3E has been reported in several human malignancies, including breast, lung, colorectal, and ovarian cancers. Depending on cellular context, INT6 has been described as possessing both tumor suppressive and oncogenic properties, reflecting its central role in coordinating selective messenger RNA translation with signaling pathways that govern proliferation and survival. As a result, eIF-3 p48 remains an important target in cancer biology, developmental biology, and studies of cellular stress responses. Researchers also use antibodies against this protein to investigate ribosome-associated processes, protein synthesis, and mechanisms controlling gene expression.
An eIF-3 p48 Antibody is a valuable reagent for studies of translation initiation, ribosome function, protein synthesis, and cancer biology. By enabling detection of the historical INT6 protein as well as its modern designation EIF3E, an eIF-3 p48 Antibody supports investigations spanning translational regulation, cellular homeostasis, and disease mechanisms.
For additional information on this protein and validated reagents for its detection, visit our EIF3E Antibody / Translation Initiation Factor Antibody page.
Optimal dilution of the eIF-3 p48 Antibody / INT6 Antibody should be determined by the researcher.
Recombinant human protein (amino acids A160-Q241) was used as the immunogen for the eIF-3 p48 antibody.
After reconstitution, the eIF-3 p48 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
INT6 antibody, EIF3E antibody, Eukaryotic Translation Initiation Factor 3 Subunit E antibody, EIF3S6 antibody, Translation Initiation Factor eIF3e antibody, p48 antibody
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