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Home >> Antibodies >> EGLN1 Antibody / PHD2

EGLN1 Antibody / PHD2 [clone 366G/76/3] (V8026)

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  Catalog No Formulation Size Price (USD)  
Image V8026-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 100 ug 519
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V8026-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 20 ug 229
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V8026SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
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SDS-PAGE analysis of purified, BSA-free EGLN1 antibody (clone 366G/76/3) as confirmation of integrity and purity.
SDS-PAGE analysis of purified, BSA-free EGLN1 antibody (clone 366G/76/3) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG1, kappa
Clone Name 366G/76/3
Purity Protein G affinity chromatography
UniProt Q9GZT9
Localization Cytoplasmic
Applications Western blot : 1-2ug/ml
Immunohistochemistry (FFPE) : 1-2ug/ml
Limitations This EGLN1 / PHD2 antibody is available for research use only.
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Description

366G/76/3 recognises human prolyl hydroxylase 2 (PHD2), a 46kDa enzyme expressed abundantly in all tissues with the highest expression in testis. Hypoxia inducible factor-1 (HIF-1) is a transcriptional complex, consisting of an alpha and beta subunit, which plays a key role in coordinating the cellular response to hypoxia. During normal oxygen conditions, the alpha subunit of HIF-1 is rapidly degraded, however when hypoxia occurs this degradation is suppressed and HIF-1 activates the transcription of various genes important for survival and adaptation to hypoxia. Prolyl hydroxylase 2 catalyses the hydroxylation of specific prolyl residues within the HIF-1 alpha subunit, thereby targeting this subunit for degradation.

Application Notes

Optimal dilution of the EGLN1 / PHD2 antibody should be determined by the researcher.

Immunogen

Amino acids 1-24 of human PHD2/EGLN1 were used as the immunogen for the EGLN1 antibody.

Storage

Store the EGLN1 / PHD2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

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