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- Tel: 858.663.9055
- Email: info@nsjbio.com
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This MAb recognizes a protein of 170kDa, identified as EGFR. EGFR is type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2, -3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, betacellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head & neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas.
Titering of the EGFR antibody may be required for optimal performance.
A portion of amino acids 344-492 from the human protein was used as the immunogen for the EGFR antibody.
Store the EGFR antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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