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- Tel: 858.663.9055
- Email: info@nsjbio.com
EDG1 (Endothelial differentiation gene 1), also called Sphingosine-1-phosphate receptor 1 (S1PR1) is the G-protein coupled receptor for Sphingosine 1-phosphate (S1P). Via its interaction with S1P, EDG1 is involved in a number of cellular processes. The binding of S1P leads to angiogenesis and tumor cell motility in cancer, and this interaction also participates in the formation of cell-cell adherens junctions. During embryogenesis, it regulates vascularization. EDG1 interacts with the serotonin receptor 5-HT1AR in the central nervous system. It is also a regulator of innate and adaptive immunity by signaling the release of T-cells from lymph nodes.
Provided assay concentrations are suggestions only, EDG1 antibody titration may be required for optimal results.
A recombinant protein fragment from the C-terminal portion of human EDG1 was used as the immunogen for this antibody.
Aliquot the EDG1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Endothelial differentiation G protein coupled receptor 1, CD363, Sphingosine 1 phosphate receptor, S1PR1 antibody
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