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Home >> Antibodies >> E-Cadherin Antibody / CDH1

E-Cadherin Antibody / CDH1 [clone SPM471] (V8270)

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  Catalog No Formulation Size Price (USD)  
Image V8270-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 100 ug 519
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V8270-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 20 ug 229
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V8270SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
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Immunofluorescent staining of human MCF7 cells with E-Cadherin antibody (clone SPM471, green) and Reddot nuclear stain (red).
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Immunofluorescent staining of human MCF7 cells with E-Cadherin antibody (clone SPM471, green) and Reddot nuclear stain (red).
IHC staining of FFPE human prostate carcinoma with E-Cadherin antibody (clone SPM471). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
IHC staining of FFPE human skin with E-Cadherin antibody (clone SPM471). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG1, kappa
Clone Name SPM471
Purity Protein G affinity chromatography
UniProt P12830
Localization Cell surface
Applications Immunofluorescence : 1-2ug/ml
Immunohistochemistry (FFPE) : 1-2ug/ml
Limitations This E-Cadherin antibody is available for research use only.
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Description

Recognizes a protein of 120-80kDa, identified as E-cadherin. Cadherins comprise a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. The classical cadherins, E-, N- and P-cadherin, consist of large extracellular domains characterized by a series of five homologous NH2 terminal repeats. The relatively short intracellular domains interact with a variety of cytoplasmic proteins, such as -catenin, to regulate cadherin function. E-cadherin plays an important role in epithelial cell adhesion. A decreased expression of E-cadherin is associated with metastatic potential and poor prognosis in breast cancer, prostate and esophageal cancer. In combination with p120 Catenin, it is useful for the differentiation between ductal (E-cadherin +) and lobular (E-cadherin -) breast carcinomas. It may also help in diagnosis of mesothelioma.

Application Notes

Optimal dilution of the E-Cadherin antibody should be determined by the researcher.

Immunogen

A recombinant human protein was used as the immunogen for this E-Cadherin antibody.

Storage

Store the E-Cadherin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

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