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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
E-cadherin Antibody Clone SPM471 / CDH1 Antibody Published Clone [clone SPM471] (V8270)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V8270-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
|
|
V8270-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V8270SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | SPM471 |
| Purity | Protein G affinity chromatography |
| UniProt | P12830 |
| Localization | Cell surface |
| Applications | Immunofluorescence : 1-2ug/ml Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This E-cadherin Antibody Clone SPM471 / CDH1 Antibody Published Clone is available for research use only. |
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E-cadherin (CDH1) is a calcium-dependent transmembrane glycoprotein that functions as a central mediator of epithelial cell-cell adhesion and is a defining component of adherens junctions. E-cadherin Antibody Clone SPM471 / CDH1 Antibody Published Clone recognizes this key epithelial protein and supports detection of junctional adhesion structures that maintain tissue architecture and cellular cohesion. E-cadherin is also referred to as Cadherin 1 antibody and is widely used as a marker of epithelial identity, differentiation, and tumor classification.
E-cadherin Antibody Clone SPM471 is distinguished by its documented use in the scientific literature, with approximately 28 peer-reviewed publications reporting application of this clone in studies of epithelial biology and cancer research. The presence of published data provides an additional layer of confidence for researchers seeking continuity with established experimental approaches. This clone SPM471 antibody is therefore positioned as a literature-supported reagent for investigation of CDH1 expression across diverse biological systems.
In experimental contexts, E-cadherin antibody is frequently used to assess epithelial phenotype and to monitor changes in cell-cell adhesion associated with processes such as epithelial-to-mesenchymal transition. Loss or reduction of CDH1 expression is strongly associated with increased cellular motility and tumor progression, while preserved expression supports epithelial structure and junctional integrity. Detection of E-cadherin is therefore essential for studies examining tumor classification, invasion, and epithelial organization.
E-cadherin forms complexes with intracellular partners including beta-catenin and alpha-catenin, linking adhesion to cytoskeletal organization and signaling pathways that regulate proliferation, polarity, and differentiation. These interactions are central to both normal epithelial function and disease-associated changes in tissue structure. Reliable detection of CDH1 enables investigation of these pathways and supports broader studies of epithelial biology.
The mouse monoclonal clone SPM471 antibody provides consistent recognition of E-cadherin and is well suited for research applications where alignment with previously published work is desirable. This E-cadherin antibody is particularly valuable for investigators seeking a well-established clone for studies of epithelial adhesion, tissue organization, and disease-related changes in CDH1 expression.
This antibody is part of the CDH1 antibody collection, where multiple E-cadherin antibody formats and applications are available for studying epithelial adhesion and cancer progression.
Optimal dilution of the E-cadherin Antibody Clone SPM471 / CDH1 Antibody Published Clone should be determined by the researcher.
A recombinant human protein was used as the immunogen for this E-Cadherin antibody.
Store the E-Cadherin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
CDH1 antibody, E-cadherin antibody, Cadherin 1 antibody, epithelial cadherin antibody, adherens junction protein antibody
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