- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
E-cadherin Antibody for IF / CDH1 Immunofluorescence Antibody - Junction Remodeling Marker [clone ECD1-2] (V7230)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V7230-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
|
|
V7230-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
|
|
V7230SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | ECD1-2 |
| Purity | Protein G affinity chromatography |
| UniProt | P12830 |
| Localization | Cytoplasmic, membranous |
| Applications | Western Blot : 1-2ug/ml Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT Immunofluorescence : 2-4ug/ml |
| Limitations | This E-cadherin Antibody for IF / CDH1 Immunofluorescence Antibody - Junction Remodeling Marker is available for research use only. |
|
Review this product on BioCompare and get a $20 Amazon gift card
|
Related Products
|
E-cadherin (CDH1) is a key regulator of epithelial adhesion that undergoes dynamic changes during processes such as tissue remodeling, differentiation, and tumor progression. Under normal conditions, CDH1 localizes to adherens junctions at the plasma membrane, where it maintains stable cell-cell contacts and supports epithelial integrity. However, during cellular transitions, CDH1 expression and localization can be altered, leading to changes in adhesion strength and tissue organization. E-cadherin Antibody for IF enables visualization of these dynamic processes, providing insight into epithelial plasticity and remodeling. CDH1 is widely recognized as E-cadherin antibody and is a central marker of epithelial state.
E-cadherin Antibody for IF / CDH1 Immunofluorescence Antibody - Junction Remodeling Marker (clone ECD1-2) is designed for imaging applications that capture changes in junctional organization and epithelial structure. The mouse monoclonal clone ECD1-2 antibody produces strong membrane staining in epithelial cell models such as MCF7, allowing visualization of both intact and altered adhesion patterns. This clone ECD1-2 antibody supports fluorescence imaging workflows focused on detecting dynamic changes in cell-cell junctions.
In immunofluorescence studies, E-cadherin antibody reveals variation in membrane staining patterns that reflect changes in junction continuity. Continuous membrane localization indicates stable epithelial adhesion, while discontinuous, punctate, or redistributed staining can indicate junction remodeling or loss of epithelial characteristics. These patterns provide valuable information about cellular state and can be used to study processes such as epithelial-to-mesenchymal transition, where CDH1 downregulation or relocalization is a key feature.
At the molecular level, E-cadherin interacts with catenin proteins and cytoskeletal components to regulate both structural integrity and intracellular signaling pathways. Changes in E-cadherin localization can influence signaling cascades that control proliferation, migration, and differentiation. E-cadherin immunofluorescence antibody enables visualization of these changes within the cellular context, supporting studies of adhesion regulation and epithelial plasticity.
This E-cadherin antibody is particularly useful for fluorescence-based analysis of epithelial remodeling, where detection of both stable and altered junctional patterns is required. The membrane-associated staining produced by clone ECD1-2 allows researchers to assess changes in epithelial organization and supports imaging workflows focused on dynamic cellular behavior.
This antibody is part of the CDH1 antibody collection, where multiple E-cadherin antibody formats and applications are available for studying epithelial adhesion and cancer progression.
Optimal dilution of the E-cadherin Antibody for IF / CDH1 Immunofluorescence Antibody - Junction Remodeling Marker should be determined by the researcher.
A full length recombinant human protein was used as the immunogen for the E-Cadherin antibody.
Store the E-Cadherin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
CDH1 antibody, E-cadherin IF antibody, junction remodeling antibody, epithelial transition marker antibody, adhesion regulation antibody
Your bulk quote request has been submitted successfully!
Please contact us if you have any questions.
Powered by Bioz
Citations(23)
