- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
DVL2 Antibody / Disheveled segment polarity protein 2 (FY12738)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY12738 | Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml | 100 ug | 439 |
DVL2 antibody detects Disheveled segment polarity protein 2, a cytoplasmic phosphoprotein that serves as a key scaffold in canonical and non-canonical Wnt signaling pathways. Encoded by the DVL2 gene on chromosome 17p13.1, this protein belongs to the Disheveled family, which transduces Wnt receptor activation into downstream signaling controlling cell polarity, differentiation, and proliferation. DVL2 contains DIX, PDZ, and DEP domains that mediate interactions with Frizzled receptors, Axin, and downstream kinases. These domains enable DVL2 to coordinate beta-catenin stabilization in the canonical pathway and planar cell polarity signaling in non-canonical branches.
Upon Wnt ligand binding, DVL2 is recruited to the membrane through Frizzled receptors, where it inhibits the beta-catenin destruction complex composed of Axin, APC, and GSK-3beta. This allows beta-catenin to accumulate and enter the nucleus, where it activates Wnt target genes that regulate growth and differentiation. In addition to its role in the canonical Wnt pathway, DVL2 participates in planar cell polarity signaling, influencing cytoskeletal organization and tissue morphogenesis. Dysregulation of DVL2 expression or phosphorylation disrupts normal Wnt signaling and has been implicated in developmental disorders and multiple cancers, including breast, colon, and lung carcinoma.
The DVL2 antibody is widely used in cell signaling, developmental biology, and oncology to monitor Wnt pathway activation and Disheveled protein dynamics. Western blot analysis identifies multiple DVL2 bands (90100 kilodaltons) corresponding to phosphorylated isoforms, while immunofluorescence reveals punctate cytoplasmic and membrane-associated staining. This antibody supports investigation of Wnt-mediated transcriptional regulation and cytoskeletal rearrangement. Because DVL2 serves as a convergence point for canonical and non-canonical pathways, it is crucial for studying cell polarity, migration, and tissue patterning.
Beyond development, DVL2 influences cancer progression, stem cell renewal, and inflammation through its regulation of beta-catenin and JNK signaling. NSJ Bioreagents provides the DVL2 antibody validated for western blotting, immunofluorescence, and immunohistochemistry, ensuring high specificity in research on Wnt signaling and tumor biology.
Optimal dilution of the DVL2 antibody should be determined by the researcher.
E.coli-derived human DVL2 recombinant protein (Position: L89-Y576) was used as the immunogen for the DVL2 antibody.
After reconstitution, the DVL2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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