DSG2 Antibody / Desmoglein 2 [clone 2B4D1] (RQ7648)

Desmoglein 2 Antibody Breast Cancer IHC. Immunohistochemistry analysis of FFPE human breast cancer tissue stained with DSG2 antibody detecting Desmoglein 2. Tumor epithelial cells show membranous and cytoplasmic staining with focal accentuation at cell-cell borders, consistent with DSG2 localization in desmosomal adhesion complexes that maintain epithelial cohesion. Surrounding stromal elements display minimal staining. Hematoxylin counterstain highlights nuclei in blue. HIER: boil tissue sections in pH 8 EDTA for 20 min and allow to cool before testing.

Desmoglein 2 Antibody Breast Cancer IHC. Immunohistochemistry analysis of FFPE human breast cancer tissue stained with DSG2 antibody detecting Desmoglein 2. Tumor epithelial cells show moderate membranous and cytoplasmic staining with focal junctional accentuation at cell-cell borders, consistent with DSG2 localization in desmosomal adhesion complexes that contribute to epithelial cohesion. Staining is heterogeneous across tumor regions, while surrounding stromal components display minimal signal. Hematoxylin counterstain highlights nuclei in blue. HIER: boil tissue sections in pH 8 EDTA for 20 min and allow to cool before testing.

Desmoglein 2 Antibody Hepatocellular Carcinoma IHC. Immunohistochemistry analysis of FFPE human hepatocellular carcinoma tissue stained with DSG2 antibody detecting Desmoglein 2. Tumor cells show membranous and cytoplasmic staining with focal accentuation at cell-cell borders, consistent with DSG2 localization in desmosomal adhesion complexes that support intercellular adhesion. Staining appears heterogeneous across tumor regions, while adjacent non-tumor areas show reduced signal. Hematoxylin counterstain highlights nuclei in blue. HIER: boil tissue sections in pH 8 EDTA for 20 min and allow to cool before testing.

Desmoglein 2 Antibody Laryngeal Squamous Cell Carcinoma IHC. Immunohistochemistry analysis of FFPE human laryngeal squamous cell carcinoma tissue stained with DSG2 antibody detecting Desmoglein 2. Tumor epithelial cells show membranous and cytoplasmic staining with prominent accentuation at cell-cell borders, consistent with DSG2 localization in desmosomal adhesion complexes that maintain epithelial cohesion. The staining highlights squamous tumor cell clusters, while surrounding stromal regions show reduced signal. Hematoxylin counterstain highlights nuclei in blue. HIER: boil tissue sections in pH 8 EDTA for 20 min and allow to cool before testing.

Desmoglein 2 Antibody Multi-Cell Line WB. Western blot analysis of human cell lysates using DSG2 antibody detecting Desmoglein 2. Lane 1: HeLa, Lane 2: K562, Lane 3: HepG2, Lane 4: A549. A band is detected at approximately 130-160 kDa, consistent with the predicted molecular weight of Desmoglein 2, with variation reflecting glycosylation of this transmembrane desmosomal cadherin. Stronger signal in epithelial-derived cell lines such as HeLa, HepG2, and A549 aligns with DSG2 expression in cells forming desmosomal adhesion complexes that support intercellular junction integrity.