- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
DPYD Antibody / Dihydropyrimidine dehydrogenase (R30854)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
R30854 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 439 |
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse, Rat |
| Format | Antigen affinity purified |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| UniProt | Q12882 |
| Applications | Western Blot : 0.5-1ug/ml Flow Cytometry : 1-3ug/million cells |
| Limitations | This DPYD antibody is available for research use only. |
|
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DPYD antibody targets Dihydropyrimidine dehydrogenase, encoded by the DPYD gene. Dihydropyrimidine dehydrogenase is a cytosolic enzyme that catalyzes the rate-limiting step in pyrimidine catabolism, converting uracil and thymine into their corresponding dihydro forms. This metabolic function is essential for maintaining nucleotide homeostasis and regulating pyrimidine turnover in mammalian cells. DPYD is most abundant in metabolically active tissues and plays a central role in coordinating nucleotide degradation with cellular metabolic demands.
Functionally, Dihydropyrimidine dehydrogenase initiates the breakdown of pyrimidine bases, enabling their reutilization or excretion. Beyond endogenous nucleotide metabolism, DPYD is critically involved in drug metabolism, as it is responsible for the catabolism of fluoropyrimidine chemotherapeutic agents such as 5-fluorouracil. Through this activity, DPYD strongly influences drug clearance and systemic exposure, making it a key determinant of treatment response and toxicity. A DPYD antibody supports studies focused on metabolic enzyme expression and drug metabolism pathways.
DPYD expression is highest in liver, where xenobiotic and nucleotide metabolism are prominent, but is also detected in other tissues including intestine, kidney, and immune cells. Expression levels can vary substantially between individuals due to genetic polymorphisms, transcriptional regulation, and physiological state. This variability contributes to inter-individual differences in pyrimidine metabolism and drug sensitivity, highlighting the importance of DPYD as a metabolic regulator with clinical relevance.
From a disease-relevance perspective, altered DPYD activity has been linked to metabolic disorders and adverse drug reactions. Reduced or absent DPYD activity is associated with severe toxicity in patients treated with fluoropyrimidine-based chemotherapy, due to impaired drug clearance. DPYD deficiency has also been studied in the context of neurological symptoms and developmental abnormalities, reflecting the broader impact of disrupted pyrimidine metabolism. These associations make DPYD an important molecule in pharmacogenomics and precision medicine research.
At the molecular level, Dihydropyrimidine dehydrogenase functions as a multi-domain flavoprotein that interacts with several cofactors to carry out redox reactions. Post-translational modifications, cofactor binding, and cellular metabolic state can influence its activity and electrophoretic behavior on SDS-PAGE without implying changes in primary sequence. A DPYD antibody supports research applications focused on pyrimidine metabolism, drug response variability, and disease-associated alterations in metabolic pathways, with NSJ Bioreagents providing reagents intended for research use.
The stated application concentrations are suggested starting amounts. Titration of the DPYD antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Amino acids 33-52 (AKKLDKKHWKRNPDKNCFNC-human) were used as the immunogen for this DPYD antibody.
After reconstitution, the DPYD antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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