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Home >> Antibodies >> Dnmt3b Antibody

Dnmt3b Antibody (F40611)

  Catalog No Formulation Size Price (USD)  
Image F40611-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 399
Image
F40611-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 185
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Western blot testing of Dnmt3b antibody at 1:2000 dilution + T47D lysate; Predicted molecular weight: 95 kDa.
Western blot testing of Dnmt3b antibody at 1:2000 dilution. Lane 1: A431 lysate; 2: A549; Predicted molecular weight: 95 kDa.
IHC analysis of FFPE human prostate carcinoma tissue stained with Dnmt3b antibody
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Purified
UniProt Q9UBC3
Applications Western blot : 1:2000
IHC (Paraffin) : 1:10-1:50
Limitations This Dnmt3b antibody is available for research use only.
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Description

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. Dnmt3b is a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF)syndrome.

Application Notes

Titration of the Dnmt3b antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 389-417 from the human protein was used as the immunogen for this Dnmt3b antibody.

Storage

Aliquot the Dnmt3b antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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