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- Tel: 858.663.9055
- Email: info@nsjbio.com
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Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.
Titration of the Dnmt3a antibody may be required due to differences in protocols and secondary/substrate sensitivity.
This Dnmt3a antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 463-497 amino acids from the central region of human Dnmt3a.
Aliquot the Dnmt3a antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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