- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
DNAAF4 Antibody / Dynein axonemal assembly factor 4 Antibody targets DNAAF4, a protein involved in the assembly of motile ciliary dynein machinery. DNAAF4 is also known as DYX1C1, a name originating from earlier investigations into developmental and neurological traits. Its established role in motile cilia centers on the maturation of axonemal dynein complexes before they are incorporated into the ciliary axoneme. These complexes generate the forces required for coordinated ciliary beating.
Motile cilia contain a highly organized array of microtubules, radial spokes, and inner and outer dynein arms. Dynein motors are large multisubunit assemblies whose heavy chains must fold and associate with accessory proteins before they can function properly. Cytoplasmic assembly factors help coordinate this process, limiting the incorporation of incomplete or unstable motor complexes into the axoneme. DNAAF4 has been implicated in this dynein preassembly network, and its disruption can compromise the formation of functional axonemal dynein arms.
Impaired motile ciliary function affects physiological processes that depend on directed fluid movement. In the respiratory tract, coordinated beating supports mucociliary clearance; in embryonic development, motile nodal cilia contribute to left-right patterning. Defects in dynein arm assembly can therefore produce features associated with primary ciliary dyskinesia, including chronic respiratory disease and laterality abnormalities. DNAAF4-related disease illustrates how a defect in motor assembly can have consequences across anatomically distinct ciliated tissues.
NSJ Bioreagents offers this DNAAF4 Antibody to support investigation of dynein preassembly and the molecular mechanisms required for motile cilium formation. Characterizing DNAAF4-associated protein networks may help explain how complex motor assemblies are prepared in the cytoplasm before their delivery to the axoneme.
Explore related research targets in our Cell Biology Antibodies collection.
Users should optimize the working dilution of the DNAAF4 Antibody / Dynein axonemal assembly factor 4 Antibody for their specific experimental setup.
The DNAAF4 Antibody was generated using e. coli-derived human DYX1C1/DNAAF4 recombinant protein (amino acids P56-Q414).
Once reconstituted, refrigerate the DNAAF4 Antibody at 4oC for no longer than one month. For extended storage, freeze aliquots at -20oC for up to six months and avoid repeated freeze-thaw cycles.
DNAAF4 antibody, Dynein axonemal assembly factor 4 antibody, DYX1 antibody, DYX1C1 antibody, DYXC1 antibody, EKN1 antibody, RD antibody
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