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Home >> Antibodies >> DNA methyltransferase 1 Antibody / Dnmt1

DNA methyltransferase 1 Antibody / Dnmt1 (RQ7268)

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  Catalog No Formulation Size Price (USD)  
Image RQ7268 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Western blot testing of mouse testis tissue lysate with DNA methyltransferase 1 antibody. Predicted molecular weight: 180-200 kDa.
Western blot testing of mouse testis tissue lysate with DNA methyltransferase 1 antibody. Predicted molecular weight: 180-200 kDa.
Availability 1-3 business days
Species Reactivity Mouse
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity purified
Buffer Lyophilized from 1X PBS with 2% Trehalose
UniProt P13864
Applications Western blot : 0.5-1ug/ml
Direct ELISA : 0.1-0.5ug/ml
Limitations This DNA methyltransferase 1 antibody is available for research use only.
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Description

DNA (cytosine-5)-methyltransferase 1 is an enzyme that in humans is encoded by the DNMT1 gene. This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants.

Application Notes

Optimal dilution of the DNA methyltransferase 1 antibody should be determined by the researcher.

Immunogen

Recombinant mouse protein (amino acids Q509-Q1577) was used as the immunogen for the DNA methyltransferase 1 antibody.

Storage

After reconstitution, the DNA methyltransferase 1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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