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- Tel: 858.663.9055
- Email: info@nsjbio.com
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Dystrophin-glycoprotein complex (DGC) connects the F-Actin cytoskeleton on the inner surface of muscle fibers to the surrounding extracellular matrix, through the cell membrane interface. A deficiency in this protein contributes to Duchenne (DMD) and Becker (BMD) muscular dystrophies. The human dystrophin gene measures 2.4 megabases, has more than 80 exons, produces a 14 kb mRNA and contains at least 8 independent tissue-specific promoters and 2 poly A sites. The dystrophin mRNA can undergo differential splicing and produce a range of transcripts that encode a large set of proteins. Dystrophin represents approximately 0.002% of total striated muscle protein and localizes to triadic junctions in skeletal muscle, where it is thought to influence calcium ion homeostasis and force transmission.
Optimal dilution of the DMD antibody should be determined by the researcher.
A portion of amino acids 114-263 from the human protein was used as the immunogen for the DMD antibody.
Aliquot the DMD antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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